Evidence map›Paper›PMID 39940413›Full record

Observational studyNutrients2025

Antioxidant Intake and Ovarian Reserve in Women Attending a Fertility Center.

Ana B Maldonado-Cárceles, Irene Souter, Ming-Chieh Li, Makiko Mitsunami, Irene Dimitriadis, Jennifer B Ford, Lidia Mínguez-Alarcón, Jorge E Chavarro, EARTH Study Team

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana B Maldonado-CárcelesDepartment of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.
Irene SouterFertility Center, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street, Suite 10A, Boston, MA 02114, USA.
Ming-Chieh LiDepartment of Health Promotion and Health Education, National Taiwan Normal University College of Education, Taipei 106, Taiwan.ORCID 0000-0003-2268-6034
Makiko MitsunamiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0002-6409-4515
Irene DimitriadisFertility Center, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street, Suite 10A, Boston, MA 02114, USA.
Jennifer B FordDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.
Lidia Mínguez-AlarcónDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.ORCID 0000-0002-2370-3900
Jorge E ChavarroDepartment of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA.
EARTH Study Team

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Brent Andrew Coull · 1985 to 2026
$44.6M
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
PCBs, Phthalates and Male Reproductive HealthR01ES009718 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HAUSER, RUSS B · 1999 to 2018
$11.6M
Maternal and Paternal Flame Retardant Exposure, Impact on Fertility and PregnancyR01ES022955 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HAUSER, RUSS B, MEEKER, JOHN D. · 2014 to 2018
$2.9M
Alfonso Martín Escudero Foundation NAChina Medical University, Taiwan CMU109-MF-118National Institutes of Healt ES000002NIDDK NIH HHS P30 DK046200NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES009718NIEHS NIH HHS R01 ES022955NIH HHS ES009718NIH HHS ES022955NIH HHS P30DK46200
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe aim of this study was to investigate the association between antioxidant intake and antral follicle count (AFC), a marker of ovarian reserve, in women attending a fertility clinic.

methodsWe conducted an observational study with 567 women undergoing infertility evaluation at the Massachusetts General Hospital Fertility Center, who were enrolled in the Environment and Reproductive Health (EARTH) study. Participants filled out the lifestyle and health questionnaires and a validated food frequency questionnaire (FFQ) for assessing habitual dietary intake and underwent a transvaginal ultrasound to measure AFC. Intake of nutrients with direct antioxidant capacity (vitamin A, C, and E and carotenoids) and intake of antioxidant food sources were estimated from the FFQ. Adjusted Poisson regression models were fitted to assess the relationships between antioxidants and AFC while adjusting for potential confounders. Non-linearity was assessed with restricted cubic splines.

resultsThe median (interquartile range) age and AFC of participants were 35.0 (32.0-38.0) years and 13 (9-18), respectively. Our findings revealed a non-linear association between lycopene intake and AFC. There was a positive linear association with the highest AFC among women consuming approximately 6000 mcg/day of lycopene (

conclusionsOur findings suggest that lycopene intake might influence the ovarian reserve in fertility patients. The observed inverse association with retinol, if confirmed, may reflect biological mechanisms different from oxidative stress. The underlying mechanisms of these associations remain to be elucidated and warrant further investigation.

Indexed as

AntioxidantsDietFertility ClinicsOvarian FollicleOvarian ReserveAdultFemaleHumansInfertility, FemaleLycopeneVitamin AYoung AdultAntioxidantsLycopeneVitamin Aantioxidantsantral follicle countfemale fertilitylycopeneovarian reserveretinol

Identifiers

PMID39940413
PMCPMC11820690

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.