Evidence map›Paper›PMID 39940416›Full record

ReviewNutrients2025

Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer's Disease.

Mona Abdelhamid, Scott E Counts, Chunyu Zhou, Hideki Hida, Jae-Il Kim, Makoto Michikawa, Cha-Gyun Jung

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Dual-Strain Psychobiotics Combining LiveFoods (Basel, Switzerland) · 2025
    Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mona AbdelhamidDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, 400 Monroe Avenue NW, Grand Rapids, MI 49503, USA.
Scott E CountsDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, 400 Monroe Avenue NW, Grand Rapids, MI 49503, USA.
Chunyu ZhouDepartment of Biochemistry, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
Hideki HidaDepartment of Neurophysiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
Jae-Il KimDepartment of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea.ORCID 0000-0002-6186-5492
Makoto MichikawaDepartment of Geriatric Medicine, School of Life Dentistry at Niigata, Nippon Dental University, Niigata 951-8580, Japan.ORCID 0000-0001-5397-2709
Cha-Gyun JungCenter for Nursing International Promotion, Nagoya City University Graduate School of Nursing, Nagoya 467-8601, Japan.ORCID 0000-0002-0225-0658

Funding

AMED JP20de010702AMED JP20dk0207050h001Grant-in-Aid for Scientific Research 24K10513
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia and is characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD that substantively modify disease progression remain a critical unmet need. In this regard, the gut microbiota is crucial in maintaining human health by regulating metabolism and immune responses, and increasing evidence suggests that probiotics, particularly beneficial bacteria, can enhance memory and cognitive functions. Recent studies have highlighted the positive effects of

Indexed as

Alzheimer DiseaseBifidobacterium breveProbioticsAmyloid beta-PeptidesAnimalsCognitive DysfunctionDisease Models, AnimalGastrointestinal MicrobiomeHumansMiceAmyloid beta-PeptidesAlzheimer’s diseaseamyloid-βBifidobacterium breve MCC1274glial activationsynapsestau phosphorylation

Identifiers

PMID39940416
PMCPMC11820889

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.