Evidence mapPaperPMID 39940678Full record

ArticleInternational journal of molecular sciences2025

In Silico and In Vivo Evaluation of Novel 2-Aminobenzothiazole Derivative Compounds as Antidiabetic Agents.

Juan Andres Alvarado Salazar, Miguel Valdes, Alejandro Cruz, Brenda Moreno de Jesús, David Patiño González, Ivonne María Olivares Corichi, Feliciano Tamay Cach, Jessica Elena Mendieta Wejebe

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. ADMET & DMPK · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan Andres Alvarado SalazarCarrera de Química Farmacéutica Biológica, Área Farmacéutica, Facultad de Estudios Superiores (FES)-Zaragoza, Universidad Nacional Autónoma de México, Batalla 5 de mayo s/n, Ejercito de Oriente, Iztapalapa, Mexico City 09230, Mexico.ORCID 0000-0002-6461-957X
Miguel ValdesLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Díaz Mirón esq. Plan de San Luis s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0001-7401-303X
Alejandro CruzLaboratorio de Química Supramolecular y Nanociencias, Departamento de Ciencias Básicas, Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Av. Acueducto s/n, Colonia Barrio La Laguna Ticomán, Mexico City 07340, Mexico.
Brenda Moreno de JesúsLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Díaz Mirón esq. Plan de San Luis s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.
David Patiño GonzálezLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Díaz Mirón esq. Plan de San Luis s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.
Ivonne María Olivares CorichiLaboratorio de Bioquímica y Estrés Oxidante, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Díaz Mirón esq. Plan de San Luis s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0002-5608-048X
Feliciano Tamay CachLaboratorio de Investigación de Bioquímica Aplicada, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Díaz Mirón esq. Plan de San Luis s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.ORCID 0000-0002-3897-6477
Jessica Elena Mendieta WejebeLaboratorio de Biofísica y Biocatálisis, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Av. Salvador Díaz Mirón esq. Plan de San Luis s/n, Casco de Santo Tomás, Miguel Hidalgo, Mexico City 11340, Mexico.

Funding

Instituto Politécnico Nacional SIP20240101Instituto Politécnico Nacional SIPMULTI2297
6 · The paper itself

Abstract

Currently, there are several drugs used for the treatment of type 2 diabetes (T2D); however, all of them have adverse effects. Benzothiazoles have a broad spectrum of biological activities such as antidiabetic. This study aimed to evaluate in silico and in vivo two series of 2-aminobenzothiazole derivatives linked to isothioureas (

Indexed as

BenzothiazolesDiabetes Mellitus, Type 2Hypoglycemic AgentsAnimalsBlood GlucoseComputer SimulationDiabetes Mellitus, ExperimentalMaleMolecular Docking SimulationPPAR gammaRatsRats, Wistaraminobenzothiazole compoundBenzothiazolesBlood GlucoseHypoglycemic AgentsPPAR gamma2-aminobenzothiazoleantidiabetic activityguanidinesisothioureastype 2 diabetes

Identifiers

PMID39940678
PMCPMC11817192

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.