Evidence map›Paper›PMID 39940681›Full record

ArticleInternational journal of molecular sciences2025

Preimplantation Genetic Testing (PGT) to Reduce the Risk for GBA-Related Parkinson's Disease: Expanding the Applications for Embryo Selection.

Shachar Zuckerman, Ari Zimran, Jeff Szer, Shoshana Revel-Vilk, Gheona Altarescu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shachar ZuckermanMedical Genetics Institute, Shaare Zedek Medical Center, The Eisenberg R&D Authority, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Ari ZimranGaucher Unit, Shaare Zedek Medical Center, The Eisenberg R&D Authority, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9103102, Israel.ORCID 0000-0003-0077-8608
Jeff SzerDepartment of Clinical Haematology, Peter MacCallum Cancer Centre, The Royal Melbourne Hospital, Melbourne 3052, Australia.ORCID 0000-0001-6783-2301
Shoshana Revel-VilkGaucher Unit, Shaare Zedek Medical Center, The Eisenberg R&D Authority, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9103102, Israel.ORCID 0000-0001-9151-0337
Gheona AltarescuMedical Genetics Institute, Shaare Zedek Medical Center, The Eisenberg R&D Authority, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9103102, Israel.ORCID 0000-0003-2796-8399

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preimplantation genetic testing (PGT) is practiced worldwide, allowing the prevention of the transmission and expression of various genetic conditions. Socio-ethical considerations of justified applications for PGT are part of an ongoing debate. Pathogenic variants in the glucocerebrosidase (

Indexed as

Gaucher DiseaseGenetic TestingGlucosylceramidaseParkinson DiseasePreimplantation DiagnosisAdultFemaleGenetic Predisposition to DiseaseHumansPregnancyGBA protein, humanGlucosylceramidaseGaucher diseaseGBA variantsParkinson’s diseasepreimplantation genetic testing

Identifiers

PMID39940681
PMCPMC11817231

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.