Evidence map›Paper›PMID 39940697›Full record

ArticleInternational journal of molecular sciences2025

Molecular and Functional Analysis of TLR 1, 2 and 6 in Peripheral Blood Monocytes of Patients with Schizophrenia: A Pilot Study.

Carlo E Sotelo-Ramírez, Marcela Valdés-Tovar, Julio Uriel Zaragoza-Hoyos, Leonardo Ortiz-López, Jesús Argueta, Mauricio Rosel-Vales, Roxana U Miranda-Labra, Beatriz Camarena

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carlo E Sotelo-RamírezDoctorado en Biología Experimental, Universidad Autónoma Metropolitana (UAM)-Iztapalapa, Mexico City 09340, Mexico.ORCID 0000-0001-9924-1434
Marcela Valdés-TovarSubdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.ORCID 0000-0002-5540-7321
Julio Uriel Zaragoza-HoyosDepartamento de Farmacogenética, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.ORCID 0000-0001-9685-6847
Leonardo Ortiz-LópezSubdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Jesús ArguetaLaboratorio de Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.ORCID 0000-0003-3668-1066
Mauricio Rosel-ValesDirección de Servicios Clínicos, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.
Roxana U Miranda-LabraDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana (UAM)-Iztapalapa, Mexico City 09340, Mexico.
Beatriz CamarenaDepartamento de Farmacogenética, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.ORCID 0000-0001-7737-501X

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías 287115_CB2016
6 · The paper itself

Abstract

Schizophrenia (SZ) is a chronic disabling mental disorder with high heritability, and several immune-regulating genes have been implicated in its pathophysiology In this study, we investigated the expression of Toll-like receptors (TLRs) 1, 2, and 6 in peripheral blood monocytes from SZ patients and healthy control subjects (HCSs) in the Mexican population, focusing on specific SZ-associated gene variants. Gene expressions were assessed by qPCR, and protein expression was measured using flow cytometry. The secretory profiles of MALP2-stimulated monocytes were evaluated through immunoproteomic arrays. Our results indicate that patients with SZ carrying the rs4833093/

Indexed as

MonocytesSchizophreniaToll-Like Receptor 1Toll-Like Receptor 2Toll-Like ReceptorsAdultCase-Control StudiesFemaleGenotypeHumansMaleMiddle AgedPilot ProjectsPolymorphism, Single NucleotideTLR1 protein, humanTLR2 protein, humanToll-Like Receptor 1Toll-Like Receptor 2Toll-Like Receptorsgene expressionschizophreniasingle-nucleotide polymorphismsTLR1TLR2TLR6

Identifiers

PMID39940697
PMCPMC11817014

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.