Evidence mapPaperPMID 39940772Full record

ReviewInternational journal of molecular sciences2025

Alzheimer's Disease: Exploring Pathophysiological Hypotheses and the Role of Machine Learning in Drug Discovery.

Jose Dominguez-Gortaire, Alejandra Ruiz, Ana Belen Porto-Pazos, Santiago Rodriguez-Yanez, Francisco Cedron

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Antioxidant and Anti-Inflammatory Activities of Probiotic Strains.International journal of molecular sciences · 2026
    Review
  7. Review
  8. Article
  9. AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025
    Review
  10. Association between Alzheimer's disease andWorld journal of biological chemistry · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jose Dominguez-GortaireDepartment of Computer Science and Information Technologies, Faculty of Computer Science, Universidade da Coruña, 15071 A Coruña, Spain.ORCID 0009-0000-1754-4889
Alejandra RuizFaculty of Medical Sciences, Universidad Central del Ecuador, Quito 170136, Ecuador.ORCID 0009-0006-5367-4625
Ana Belen Porto-PazosDepartment of Computer Science and Information Technologies, Faculty of Computer Science, Universidade da Coruña, 15071 A Coruña, Spain.ORCID 0000-0003-1428-2523
Santiago Rodriguez-YanezDepartment of Computer Science and Information Technologies, Faculty of Computer Science, Universidade da Coruña, 15071 A Coruña, Spain.ORCID 0000-0002-6781-7838
Francisco CedronDepartment of Computer Science and Information Technologies, Faculty of Computer Science, Universidade da Coruña, 15071 A Coruña, Spain.ORCID 0000-0002-6962-4749

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a major neurodegenerative dementia, with its complex pathophysiology challenging current treatments. Recent advancements have shifted the focus from the traditionally dominant amyloid hypothesis toward a multifactorial understanding of the disease. Emerging evidence suggests that while amyloid-beta (

Indexed as

Alzheimer DiseaseDrug DiscoveryMachine LearningAmyloid beta-PeptidesAnimalsHumanstau ProteinsAmyloid beta-Peptidestau ProteinsAI applicationsmachine learningmitochondrial dysfunctionsmolecular dockingneuroinflammationpathophysiologytherapeutic targetvirtual screening

Identifiers

PMID39940772
PMCPMC11816687

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.