Evidence map›Paper›PMID 39940876›Full record

ArticleInternational journal of molecular sciences2025

Altered Sertoli Cell Function Contributes to Spermatogenic Arrest in Dogs with Chronic Asymptomatic Orchitis.

Pauline Rehder, Eva-Maria Packeiser, Hanna Körber, Sandra Goericke-Pesch

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. miR-132-y TargetsBiomolecules · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pauline RehderReproductive Unit-Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany.
Eva-Maria PackeiserReproductive Unit-Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany.ORCID 0000-0001-6694-3851
Hanna KörberReproductive Unit-Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany.
Sandra Goericke-PeschReproductive Unit-Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, 30559 Hannover, Germany.ORCID 0000-0002-4327-9780

Funding

Deutsche Forschungsgemeinschaft 491094227GkF NA
6 · The paper itself

Abstract

Acquired infertility due to chronic asymptomatic orchitis (CAO) is a common finding in male dogs. It is characterized by spermatogenic arrest, a significant reduction in spermatogonia, immune cell infiltration and a disruption of the blood-testis barrier. Sertoli cells are a key factor for spermatogenesis and the testicular micromilieu. We hypothesize altered Sertoli cell function to be involved in the pathogenesis of canine CAO. Consequently, the aim was to gain further insights into the spermatogonial stem cell niche and Sertoli cell function in CAO-affected dogs. Therefore, the testicular expression of the Sertoli cell-derived factors

Indexed as

Dog DiseasesOrchitisSertoli CellsSpermatogenesisAnimalsBone Morphogenetic Protein 4Chemokine CXCL12Chronic DiseaseDogsFibroblast Growth Factor 2Glial Cell Line-Derived Neurotrophic FactorInfertility, MaleMaleTestisWnt-5a ProteinBone Morphogenetic Protein 4Chemokine CXCL12Fibroblast Growth Factor 2Glial Cell Line-Derived Neurotrophic FactorWnt-5a ProteinazoospermiabFGFBMP4canine testischronic orchitisCXCL12GDNFLDHCSertoli cellsWNT5A

Identifiers

PMID39940876
PMCPMC11817828

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.