Evidence map›Paper›PMID 39940941›Full record

ArticleInternational journal of molecular sciences2025

Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice.

Cheryl A Frye, Daina M Cleveland, Anjali Sadarangani, Jennifer K Torgersen

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. GABADrug design, development and therapy · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cheryl A FryeComprehensive Neuropsychological Services, 490 Western Avenue, Albany, NY 12203, USA.ORCID 0000-0002-8452-296X
Daina M ClevelandComprehensive Neuropsychological Services, 490 Western Avenue, Albany, NY 12203, USA.
Anjali SadaranganiComprehensive Neuropsychological Services, 490 Western Avenue, Albany, NY 12203, USA.
Jennifer K TorgersenComprehensive Neuropsychological Services, 490 Western Avenue, Albany, NY 12203, USA.

Funding

in publication in publication
6 · The paper itself

Abstract

Progestogens' anti-anxiety and anti-depressive effects and mechanisms are not well-understood. Progestogens are hypothesized to have anti-anxiety and anti-depressive effects on behavior, independent of actions at nuclear progestin receptors (NPRs) and dependent on allopregnanolone (5α-pregnan-3α-ol-20-one; 3α,5α-THP), a 5α-reduced, neuroactive metabolite of progesterone (P

Indexed as

Anti-Anxiety AgentsAnxietyBrain-Derived Neurotrophic FactorCholestenone 5 alpha-ReductaseDepressionHippocampusProgesteroneReceptors, ProgesteroneAnimalsBehavior, AnimalFemaleMiceMice, Inbred C57BLMice, KnockoutPregnanoloneAnti-Anxiety AgentsBdnf protein, mouseBrain-Derived Neurotrophic FactorCholestenone 5 alpha-ReductasePregnanoloneProgesteroneReceptors, Progesteroneelevated plus mazeforced swimneuroactive steroidneurosteroidnon-genomicopen field

Identifiers

PMID39940941
PMCPMC11818940

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.