Evidence map›Paper›PMID 39941040›Full record

ArticleInternational journal of molecular sciences2025

Design of New Daunorubicin Derivatives with High Cytotoxic Potential.

Aleksandra A Kalashnikova, Altynkul B Toibazarova, Oleg I Artyushin, Lada V Anikina, Anastasiya A Globa, Zinaida S Klemenkova, Maxim V Andreev, Eugene V Radchenko, Vladimir A Palyulin, Yulia R Aleksandrova and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Aleksandra A KalashnikovaNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, Russia.
Altynkul B ToibazarovaLaboratory of Engineering Profile, Korkyt Ata Kyzylorda University, Ayteke bi Str., 29A, Kyzylorda 120014, Kazakhstan.
Oleg I ArtyushinNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, Russia.
Lada V AnikinaInstitute of Physiologically Active Compounds of the FSBIS of the Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of the RAS, 1 Severnyi Proezd, Chernogolovka 142432, Russia.
Anastasiya A GlobaInstitute of Physiologically Active Compounds of the FSBIS of the Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of the RAS, 1 Severnyi Proezd, Chernogolovka 142432, Russia.ORCID 0000-0003-1766-173X
Zinaida S KlemenkovaNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, Russia.
Maxim V AndreevNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, Russia.
Eugene V RadchenkoDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, Moscow 119991, Russia.ORCID 0000-0002-2091-7022
Vladimir A PalyulinDepartment of Chemistry, Lomonosov Moscow State University, Leninskie Gory, Moscow 119991, Russia.ORCID 0000-0001-8792-8386
Yulia R AleksandrovaNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, Russia.ORCID 0000-0002-5370-3370
Marat I SyzdykbayevDepartment of Biology, Geography and Chemistry, Laboratory of Engineering Profile, Korkyt Ata Kyzylorda University, Ayteke bi Str., 29A, Kyzylorda 120014, Kazakhstan.
Nurbol O AppazovLaboratory of Engineering Profile, Department of Engineering Technology, Korkyt Ata Kyzylorda University, Ayteke bi Str., 29A, Kyzylorda 120014, Kazakhstan.ORCID 0000-0001-8765-3386
Vladimir N ChubarevDepartment of Pharmacology, The Institute of Pharmacy Named after A.P. Nelyubin, Sechenov University, Trubetskaya St., 8-2, Moscow 119991, Russia.ORCID 0000-0002-7047-1436
Margarita E NeganovaNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, Russia.ORCID 0000-0001-9346-5920
Valery K BrelNesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilova St. 28, Bld. 1, Moscow 119991, Russia.

Funding

the Non-Profit Joint-Stock Company "Korkyt Ata Kyzylorda University" the Non-Profit Joint-Stock Company "Korkyt Ata Kyzylorda University"
6 · The paper itself

Abstract

Chemotherapy with anthracycline antibiotics is a common method of treating tumors of various etiologies. To create more highly effective cytostatics based on daunorubicin, we used the method of reductive amination using polyalkoxybenzaldehydes. The obtained derivatives of the anthracycline structure have much greater cytotoxicity compared to daunorubicin due to increased affinity for DNA, the ability to disrupt the cell cycle, and their inhibition of the glycolysis process, which is confirmed by data from extensive biological studies and the results of molecular modeling.

Indexed as

Antibiotics, AntineoplasticAntineoplastic AgentsDaunorubicinDrug DesignCell CycleCell Line, TumorCell ProliferationCell SurvivalGlycolysisHumansAntibiotics, AntineoplasticAntineoplastic AgentsDaunorubicinanthracycline antibioticscell cyclechemotherapycytotoxicitydaunorubicinglycolysis

Identifiers

PMID39941040
PMCPMC11818560

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.