Evidence map›Paper›PMID 39942328›Full record

ArticleMaterials (Basel, Switzerland)2025

Optimization of Peri-Implant Bone Repair in Estrogen-Deficient Rats on a Cafeteria Diet: The Combined Effects of Systemic Risedronate and Genistein-Functionalized Implants.

Tatiany Aparecida de Castro, Jaqueline Suemi Hassumi, Gabriela Morais Julião, Marina Corrêa Dutra, Ana Cláudia Ervolino da Silva, Naara Gabriela Monteiro, Fábio Roberto de Souza Batista, Gabriel Mulinari-Santos, Paulo Noronha Lisboa-Filho, Roberta Okamoto

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Protective Effects ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tatiany Aparecida de CastroDepartamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Araçatuba 16015-050, SP, Brazil.
Jaqueline Suemi HassumiDepartamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Araçatuba 16015-050, SP, Brazil.
Gabriela Morais JuliãoDepartamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Araçatuba 16015-050, SP, Brazil.
Marina Corrêa DutraDepartamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Araçatuba 16015-050, SP, Brazil.
Ana Cláudia Ervolino da SilvaDepartamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Araçatuba 16015-050, SP, Brazil.
Naara Gabriela MonteiroDepartamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Araçatuba 16015-050, SP, Brazil.ORCID 0000-0002-2857-9195
Fábio Roberto de Souza BatistaDepartamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Araçatuba 16015-050, SP, Brazil.
Gabriel Mulinari-SantosDepartamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Araçatuba 16015-050, SP, Brazil.ORCID 0000-0003-4489-6868
Paulo Noronha Lisboa-FilhoDepartamento de Física e Meteorologia, Faculdade de Ciências de Bauru, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Bauru 17033-360, SP, Brazil.ORCID 0000-0002-7734-4069
Roberta OkamotoDepartamento de Ciências Básicas, Faculdade de Odontologia de Araçatuba, Universidade Estadual Paulista Júlio de Mesquita Filho, UNESP, Araçatuba 16015-050, SP, Brazil.ORCID 0000-0002-6773-6966

Funding

PIBIC/CNPq 6944/2022-4Research Productivity Scholarship/CNPq 309408/2020-2São Paulo Research Foundation 2020/10462-5; 2021/11045-1
6 · The paper itself

Abstract

Estrogen deficiency, coupled with a cafeteria diet (CD), can impair peri-implant bone repair, posing a significant challenge to implant success in affected individuals. Thus, it is crucial to explore strategies for implant functionalization and systemic treatments that could alleviate these bone alterations. This study aimed to assess peri-implant bone repair in ovariectomized (OVX) rats subjected to a CD, with a focus on implants functionalized with genistein (GEN), compared to conventional implants (CONV), and the effects of systemic treatment with risedronate sodium (RIS). In total, thirty-six female rats were assigned to three groups: rats with estrogen (SHAM), rats with estrogen deficiency and CD (OVX-CD), rats with estrogen deficiency, CD, and systemic RIS treatment (OVX-CD-RIS). All rats underwent bilateral extraction of the first upper molars followed by implant installation. Each group was further subdivided based on implant type: conventional implants (CONV) or GEN-functionalized implants, resulting in six subgroups (

Indexed as

genisteinlayer-by-layernanoparticlesosseointegrationosteoporosis

Identifiers

PMID39942328
PMCPMC11818843

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.