Evidence map›Paper›PMID 39943676›Full record

ArticlePhysiological reports2025

Organ development in growth-restricted fetuses in the reduced uterine perfusion pressure rat model: A vascular approach of brain, heart, and kidney.

J Alhama-Riba, C M van Kammen, K T Nijholt, D Viveen, K Amarouchi, D Shasha, M M Krebber, F E Hoebeek, A T Lely, C H A Nijboer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

J Alhama-RibaDivision of Woman & Baby, Department for Developmental Origins of Disease (DDOD), Brain Center UMC, Wilhelmina Children's Hospital, Utrecht University, Utrecht, the Netherlands.
C M van KammenDivision of LAB, Department CDL Research, Nanomedicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
K T NijholtDivision of Woman & Baby, Department of Obstetrics, Wilhelmina Children's Hospital, Utrecht University, Utrecht, the Netherlands.
D ViveenDivision of Woman & Baby, Department for Developmental Origins of Disease (DDOD), Brain Center UMC, Wilhelmina Children's Hospital, Utrecht University, Utrecht, the Netherlands.
K AmarouchiDivision of Woman & Baby, Department for Developmental Origins of Disease (DDOD), Brain Center UMC, Wilhelmina Children's Hospital, Utrecht University, Utrecht, the Netherlands.
D ShashaDivision of Woman & Baby, Department for Developmental Origins of Disease (DDOD), Brain Center UMC, Wilhelmina Children's Hospital, Utrecht University, Utrecht, the Netherlands.
M M KrebberDivision of Internal Medicine and Dermatology, Department of Nephrology and Hypertension, University Medical Center, Utrecht, the Netherlands.
F E HoebeekDivision of Woman & Baby, Department for Developmental Origins of Disease (DDOD), Brain Center UMC, Wilhelmina Children's Hospital, Utrecht University, Utrecht, the Netherlands.
A T LelyDivision of Woman & Baby, Department of Obstetrics, Wilhelmina Children's Hospital, Utrecht University, Utrecht, the Netherlands.
C H A NijboerDivision of Woman & Baby, Department for Developmental Origins of Disease (DDOD), Brain Center UMC, Wilhelmina Children's Hospital, Utrecht University, Utrecht, the Netherlands.
F TerstappenDivision of Woman & Baby, Department for Developmental Origins of Disease (DDOD), Brain Center UMC, Wilhelmina Children's Hospital, Utrecht University, Utrecht, the Netherlands.ORCID https://orcid.org/0000-0002-6587-1320

Funding

EC | Horizon 2020 Framework Programme (H2020) No 874721Nierstichting (Dutch Kidney Foundation) 23OSR026Wilhelmina Kinderziekenhuis (WKZ) Booster grantWilhelmina Kinderziekenhuis (WKZ) Clinical Research FellowshipZonMW MKMD neutral results grant 114024183
6 · The paper itself

Abstract

Fetal growth restriction (FGR) increases the risk of developing cardiovascular, renal, and neurovascular diseases. An overlapping vascular pathophysiology as a response to chronic hypoxia and circulatory redistribution in utero, might underlie this lifelong burden. This study aims to assess potential vascular detoriations in multiple organs following FGR using the Reduced Uterine Perfusion Pressure (RUPP) rat model. The fetal brain, heart, and kidney were collected (RUPP n = 16 vs. sham n = 13) at embryonic day (E)19 for histological assessment of various aspects of vascular and structural development. Results indicated similar microvascularisation in all organs between the groups. Structural assessment demonstrated a decreased brain area and thickness of the somatosensory cortex and thicker right ventricular wall of the heart (not driven by increased proliferation) in RUPP fetuses, and no differences in renal development. In conclusion, the fetal stage might be too early to detect detoriation in organ vasculature, while this study did reveal subtle alterations in structural development of mostly the brain, followed by the heart with sparing of the kidneys. Potentially compensatory mechanisms may be at play at this fetal stage. Nevertheless, small subclinical adaptations could make the FGR offspring more susceptible for second hits with manifestation at older age.

Indexed as

BrainFetal Growth RetardationHeartKidneyUterusAnimalsFemaleFetal DevelopmentPregnancyRatsbrainfetal growth restrictionheartkidneyvascular

Identifiers

PMID39943676
PMCPMC11821727

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.