Evidence mapPaperPMID 39945201Full record

ReviewAmerican journal of reproductive immunology (New York, N.Y. : 1989)2025

Understanding the Associations of Urogenital Microbiomes With Fertility and In Vitro Fertilization.

Alicia R Berard, Douglas K Brubaker, Dalí X Nemecio, Christina Farr Zuend

Abstract readReview
In one paragraph

Review in American journal of reproductive immunology (New York, N.Y. : 1989), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alicia R BerardDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Douglas K BrubakerDepartment of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.
Dalí X NemecioDepartment of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.
Christina Farr ZuendDepartment of Pathology, Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.ORCID 0009-0001-4165-6909

Funding

The role of the female and male reproductive microenvironment in fertility fitnessR01HD110367 · NICHD · CASE WESTERN RESERVE UNIVERSITY · 2023 to 2025
$1.2M
Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health R01HD110367NICHD NIH HHS R01 HD110367
6 · The paper itself

Abstract

Infertility, defined as the inability to establish a clinical pregnancy after a year of regular, unprotected sexual intercourse, impacts 8%-12% of couples worldwide. Many of these couples turn to in vitro fertilization (IVF) to build their families. The success rate of IVF procedures is variable, with estimates of up to 40% of embryo transfers being unsuccessful. Herein we review the existing literature on the role of the female and male urogenital microbiomes and genital inflammation on fertility and IVF outcomes. We discuss the microbiome across the female reproductive tract (FRT) and identify associations with female infertility, female genital tract inflammation, and success of IVF procedures. We also discuss the male urogenital microbiome and the associations between microbial taxa, genital inflammation, and male fertility parameters. Finally, we consider microbial transfer within couples and the impact this may have on fertility and the success of IVF procedures.

Indexed as

FertilityFertilization in VitroInfertility, FemaleMicrobiotaUrogenital SystemFemaleHumansMalePregnancyendometrial microbiomegenital inflammationinfertilityIVFpenile microbiomeseminal microbiomevaginal microbiome

Identifiers

PMID39945201
PMCPMC11822749

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.