ArticleActa paediatrica (Oslo, Norway : 1992)2025
Sex Differences in Body Composition and MASLD in Children With Overweight and Obesity.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Dynamics of Body Composition and Metabolic Risk in Adolescents With Obesity Under GLP-1 Receptor Agonist Therapy.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Somatotype and body composition of healthy adult men and women and their contribution to civilization diseases risk.Journal of physiological anthropology · 2026Article
- Body composition shapes cardiometabolic risk in children with multifactorial dyslipidemia.Frontiers in nutrition · 2025Article
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Authors and funding
12 authors.
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Abstract
aimTo explore the relationships between body composition, indices of hepatic fibrosis, and sonographic evidence of hepatic steatosis in children with overweight and obesity.
methodsOne hundred and seventy individuals (age 12.7 ± 3.4 years, 38.2% boys) with overweight/obesity (BMI z-score 2.02 ± 0.54) underwent bioelectrical impedance analysis (fat percentage, truncal-to-total fat ratio, muscle-to-fat ratio [MFR]). Hepatic assessments included ultrasonography to detect liver steatosis, alanine transaminase (ALT), aspartate aminotransferase (AST)/ALT ratio, and nonalcoholic fatty liver disease fibrosis score (NFS). A forward logistic regression model, adjusting for sex, age, and socio-economic position, was conducted.
resultsThe odds for sonographic hepatic steatosis increased by 3.8-fold for each SD decrease in MFR z-score (OR = 0.263, 95% CI [0.067-1.031], p = 0.05). The strongest correlation among boys was between MFR z-score and AST/ALT ratio (r = 0.530, p < 0.001), whereas the strongest correlation among girls was between fat percentage and NFS (r = 0.503, p < 0.001). Individuals with sonographic hepatic steatosis had higher fat mass (p = 0.003), lower MFR z-score (p = 0.020), greater insulin resistance (p = 0.018), and atherogenic dyslipidemic index (p = 0.037) compared to those without.
conclusionsWe identified sex differences in the association between body composition and hepatic fibrosis indices. The relationship between adverse body composition and increased odds of hepatic steatosis underscores the importance of its assessment within this at-risk population.
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