Observational studyChest2025
The Association of Interstitial Lung Abnormalities and Preserved Ratio Impaired Spirometry With Mortality.
Observational study in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Deep learning approach for probabilistic pulmonary function estimation from chest X-ray and peak expiratory flow rate.Communications medicine · 2026Article
- Phenotyping preserved ratio impaired spirometry (PRISm) using quantitative high-resolution computed tomography imaging features.Quantitative imaging in medicine and surgery · 2026Article
- Cryobiopsy at the dawn of fibrosis: unlocking early diagnosis and therapeutic windows.Frontiers in medicine · 2026Review
- The Inflammation-Metabolism Axis in Preserved Ratio Impaired Spirometry: Pathogenic Mechanisms and Translational Implications.Journal of inflammation research · 2026Review
- Response.Chest · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundPreserved ratio impaired spirometry (PRISm) findings are heterogeneous and include restrictive lung disease. Interstitial lung abnormalities (ILAs) may represent early interstitial lung disease. The relationship between PRISm and ILAs is not well understood. RESEARCH QUESTION: What is the prevalence of ILAs in PRISm compared with normal spirometry findings, what are risk factors for ILAs within PRISm, and how do ILAs modify the association of PRISm and mortality? STUDY DESIGN AND
methodsIn Genetic Epidemiology of COPD study participants with baseline spirometry results and chest CT scans, we examined those with normal spirometry findings (FEV
resultsWe included 4,494 participants with normal spirometry findings and 1,262 participants with PRISm. ILAs were present in 93 participants (7%) with PRISm and in 180 participants (4%) with normal spirometry findings. PRISm findings were associated with increased odds (OR, 1.74; 95% CI, 1.33-2.27; P < .001) of ILAs compared with normal spirometry findings. Among participants with PRISm, older age, increased smoke exposure, lower lung function, and increased airway wall thickness were associated with ILA. ILAs were associated with increased mortality (adjusted hazard ratio, 2.58; 95% CI, 1.49-4.45).
interpretationOur results show that among patients with PRISm, ILAs are associated with increased all-cause mortality, as well as increased age, smoke exposure, lower lung function, and increased airway wall thickness. CLINICAL TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT000608764; URL: www. CLINICALTRIALS: gov.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.