Evidence map›Paper›PMID 39947648›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025

Mass cytometric analysis of circulating monocyte subsets in a murine model of diabetic gastroparesis.

Shefaa AlAsfoor, Erik Jessen, Suraj R Pullapantula, Jennifer R Voisin, Linda C Hsi, Kevin D Pavelko, Samera Farwana, Jack A Patraw, Xin-Yi Chai, Sihan Ji and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Shefaa AlAsfoorEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-2179-3682
Erik JessenDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, United States.
Suraj R PullapantulaEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.
Jennifer R VoisinEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.
Linda C HsiEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.
Kevin D PavelkoImmune Monitoring Core, Office of Core Shared Services, Mayo Clinic, Rochester, Minnesota, United States.
Samera FarwanaImmune Monitoring Core, Office of Core Shared Services, Mayo Clinic, Rochester, Minnesota, United States.
Jack A PatrawEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.
Xin-Yi ChaiEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.
Sihan JiEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.
Michael A StrausbauchImmune Monitoring Core, Office of Core Shared Services, Mayo Clinic, Rochester, Minnesota, United States.
Gianluca CiprianiEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.
Lai WeiEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.
David R LindenEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.
Ruixue HouGastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States.
Richard MyersGastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., San Diego, California, United States.
Yogesh BhattaraiGastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., San Diego, California, United States.ORCID 0000-0002-2349-3958
Jill WykoskyGastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States.
Alan J BurnsGastrointestinal Drug Discovery Unit, Takeda Development Center Americas, Inc., Cambridge, Massachusetts, United States.
Surendra DasariDepartment of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States.
Gianrico FarrugiaEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-3473-5235
Madhusudan GroverEnteric Neuroscience Program, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-5092-0831

Funding

Pathophysiology of Diabetic GastroparesisR01DK127992 · NIDDK · MAYO CLINIC ROCHESTER · PI FARRUGIA, GIANRICO, GROVER, MADHUSUDAN · 2021 to 2024
$2.2M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK 127992NIDDK NIH HHS R01 DK127992Takeda Pharmaceuticals U.S.A. (TPUSA)
6 · The paper itself

Abstract

Circulating monocytes (Mo) are precursors to a subset of gastric resident muscularis macrophages. Changes in muscularis macrophages (MMs) result in delayed gastric emptying (DGE) in diabetic gastroparesis. However, the dynamics of Mo in the development of DGE in an animal model are unknown. Using cytometry by time-of-flight and computational approaches, we show a high heterogeneity within the Mo population. In DGE mice, via unbiased clustering, we identified two reduced Mo clusters that exhibit migratory phenotype (Ly6C

Indexed as

Diabetes Mellitus, ExperimentalGastroparesisMonocytesAnimalsCell MovementChemokine CCL2Disease Models, AnimalFlow CytometryGastric EmptyingMacrophagesMaleMiceMice, Inbred C57BLReceptors, CCR2Ccr2 protein, mouseChemokine CCL2Receptors, CCR2circulating monocytesdelayed gastric emptyingimmune cellssurface proteins

Identifiers

PMID39947648
PMCPMC12282717

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.