Evidence map›Paper›PMID 39947683›Full record

ArticleAJNR. American journal of neuroradiology2025

Implications of Hydrocephalus on FDG-PET Statistical Parametric Mapping Analysis in Neurodegenerative Disease Evaluation.

Andres Ricaurte-Fajardo, Ana M Franceschi, Debra D'Angelo, Aliah McCalla, Miran Salgado, Moath Hamed, Brielle Intorcia, Carlyn Wisherop, Samantha A Keil, Anna S Nordvig and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andres Ricaurte-FajardoFrom the Department of Radiology (A.R.-F., A.M., B.I., C.W., S.A.K., J.R.O., G.C.C., J.I.), Weill Cornell Medicine, New York, New York.ORCID https://orcid.org/0000-0002-7374-4460
Ana M FranceschiDepartment of Radiology (A.M.F.), Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, New York.ORCID https://orcid.org/0000-0003-2577-9738
Debra D'AngeloDepartment of Population Health Sciences (D.D.), Weill Cornell Medicine, New York, New York.
Aliah McCallaFrom the Department of Radiology (A.R.-F., A.M., B.I., C.W., S.A.K., J.R.O., G.C.C., J.I.), Weill Cornell Medicine, New York, New York.
Miran SalgadoDepartment of Neurology (M.S., M.H.), New York Presbyterian Brooklyn Methodist, New York, New York.
Moath HamedDepartment of Neurology (M.S., M.H.), New York Presbyterian Brooklyn Methodist, New York, New York.
Brielle IntorciaFrom the Department of Radiology (A.R.-F., A.M., B.I., C.W., S.A.K., J.R.O., G.C.C., J.I.), Weill Cornell Medicine, New York, New York.ORCID https://orcid.org/0009-0004-6632-438X
Carlyn WisheropFrom the Department of Radiology (A.R.-F., A.M., B.I., C.W., S.A.K., J.R.O., G.C.C., J.I.), Weill Cornell Medicine, New York, New York.
Samantha A KeilFrom the Department of Radiology (A.R.-F., A.M., B.I., C.W., S.A.K., J.R.O., G.C.C., J.I.), Weill Cornell Medicine, New York, New York.
Anna S NordvigDepartment of Neurology (A.S.N.), Weill Cornell Medicine, New York, New York.
Joseph R OsborneFrom the Department of Radiology (A.R.-F., A.M., B.I., C.W., S.A.K., J.R.O., G.C.C., J.I.), Weill Cornell Medicine, New York, New York.ORCID https://orcid.org/0000-0003-0232-5960
Gloria C ChiangFrom the Department of Radiology (A.R.-F., A.M., B.I., C.W., S.A.K., J.R.O., G.C.C., J.I.), Weill Cornell Medicine, New York, New York.ORCID https://orcid.org/0000-0001-9925-0816
Jana IvanidzeFrom the Department of Radiology (A.R.-F., A.M., B.I., C.W., S.A.K., J.R.O., G.C.C., J.I.), Weill Cornell Medicine, New York, New York jai9018@med.cornell.edu.ORCID https://orcid.org/0000-0002-6470-5400

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeFDG-PET is critical in the diagnosis of neurodegenerative disease. Quantitative analysis with statistical parametric mapping (SPM) has been shown to improve the diagnostic accuracy of FDG-PET and has been incorporated in clinical workflows. This study aimed to assess the effects of hydrocephalus on the accuracy of FDG-PET SPM analysis, focusing on the cingulate gyrus regions, which are of particular interest in dementia evaluation and are adjacent to the lateral ventricles. MATERIALS AND

methodsIn this retrospective institutional review board-approved study, patients who underwent brain FDG-PET/CT or PET/MRI were evaluated. Inclusion criteria were a clinical history of cognitive impairment/suspected neurodegenerative disease and MRI evidence of communicating hydrocephalus. Region-specific

resultsThe study included 48 patients (17 women; mean age, 76 years). SPM analysis found significantly lower cingulate

conclusionsOur study highlights hydrocephalus as an important pitfall of FDG-PET SPM, particularly when analyzing the cingulate regions, integral to the clinical evaluation of dementia. Awareness of this pitfall can improve diagnostic accuracy and thus improve clinical outcomes in this growing patient population.

Indexed as

Fluorodeoxyglucose F18HydrocephalusNeurodegenerative DiseasesPositron-Emission TomographyAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRadiopharmaceuticalsReproducibility of ResultsRetrospective StudiesSensitivity and SpecificityFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID39947683
PMCPMC12453496

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.