Evidence map›Paper›PMID 39948072›Full record

Trial reportNature communications2025

Differences in natriuretic peptide response in self-identified white and black individuals: a physiological clinical trial.

Naman S Shetty, Mokshad Gaonkar, Nirav Patel, Nehal Vekariya, Krishin Yerabolu, Jasninder S Dhaliwal, Thomas W Buford, Barbara Gower, Peng Li, Thomas J Wang and 2 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03070184 (Racial Differences in the Natriuretic Peptide Response to Exercise and Beta-blockers), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03070184 phase2completednot on this map

Racial Differences in the Natriuretic Peptide Response to Exercise and Beta-blockers

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2017 to 2024Enrolled80ConditionsHealthy, Pre HypertensionArmsExercise capacity VO2 max determination, Standardized meals, Exercise challenge, Metoprolol Succinate ER
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Naman S ShettyDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Mokshad GaonkarDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Nirav PatelDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Nehal VekariyaDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Krishin YeraboluDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Jasninder S DhaliwalDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Thomas W BufordDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-9541-4358
Barbara GowerDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.
Peng LiSchool of Nursing, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-9026-9999
Thomas J WangDepartment of Medicine, University of Texas-Southwestern Medical Center, Dallas, TX, USA.
Garima AroraDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA.
Pankaj AroraDivision of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA. parora@uabmc.edu.ORCID http://orcid.org/0000-0003-2420-3550

Funding

UAB Nutrition Obesity Research Center (NORC)P30DK056336 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2000 to 2025
$6.0M
Natriuretic Peptide-Renin-Angiotensin-Aldosterone System Rhythm Axis and Nocturnal Blood PressureR01HL160982 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 to 2025
$2.9M
MECHANISMS OF HYPERTENSION AND CARDIOVASCULAR DISEASEST32HL007457 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 1985 to 2025
$1.7M
The Effects of Neprilysin Inhibition on Cardiometabolic Health in Black IndividualsR01HL163852 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 to 2025
$1.5M
Atrial Natriuretic Peptide and Regulation of Cardiometabolic Health: A Genotype-Guided Human Physiological StudyR01HL163081 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$742k
NHLBI NIH HHS K23 HL146887NHLBI NIH HHS R01 HL160982NHLBI NIH HHS R01 HL163081NHLBI NIH HHS R01 HL163852NHLBI NIH HHS T32 HL007457NIDDK NIH HHS P30 DK056336
6 · The paper itself

Abstract

Black individuals have lower plasma natriuretic peptide (NP) concentrations than white individuals. However, race-based differences in the NP response to physiological perturbations are unknown. In this physiological trial (NCT#03070184), we measured the NP [mid-regional atrial NP (MR-proANP), N-terminal pro-B-type NP (NT-proBNP), and BNP] response to physiological perturbations among healthy, self-identified Black and white participants aged 18-40 years. The primary and secondary outcomes were the change in plasma NP concentrations at 6 weeks after metoprolol (initiated at 50 mg/day and doubled every 2 weeks) and standardized, aerobic exercise (70% of their maximal oxygen uptake on a salt-standardized background), respectively. Among 40 Black [median age: 27 (22, 32) years; 21 (52.5%) women] and 40 white [median age: 25 (20, 30) years; 19 (47.5%) women] participants, exercise increased MR-proANP (Black: 35%; white: 43%), NT-proBNP (Black: 11%; white: 23%), and BNP (Black: 59%; white: 61%) in both self-reported races. Exercise was associated with an increase in plasma MR-proANP (p

Indexed as

Atrial Natriuretic FactorBlack or African AmericanNatriuretic Peptide, BrainNatriuretic PeptidesPeptide FragmentsWhiteAdolescentAdultBlack PeopleExerciseFemaleHumansMaleMetoprololYoung AdultAtrial Natriuretic FactorMetoprololNatriuretic Peptide, BrainNatriuretic PeptidesPeptide Fragmentspro-brain natriuretic peptide (1-76)

Identifiers

PMID39948072
PMCPMC11825667

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.