ArticleScientific reports2025
Changes in insulin, adiponectin and lipid concentrations with age are associated with frailty and reduced quality of life in dogs.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The relationship between parity and late-life frailty: companion dogs as a preclinical model for evaluating factors that aggravate or mitigate the frailty cost of reproduction.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- High molecular weight adiponectin as an adjunct biomarker for insulin dysregulation in equids.Journal of veterinary internal medicine · 2026Article
- OLD DOG - Validating the dog as an animal model for human aging studies.The Journal of frailty & aging · 2026Article
- Characterising Reference Intervals in Clinically Normal Red Wolves (Canis rufus): A Baseline for the Detection of Clinical Disease.Veterinary medicine and science · 2026Article
- Exploratory evaluation of equine placental extract supplementation on ageing indicators in geriatric dogs: a single-arm pre-post study.BMC veterinary research · 2026Article
- Cohort profile of the first 2,000 canine enrolees in the Mars Petcare Biobank: demographic, hematologic and serum biochemistry results from March 2022 to December 2024.BMC veterinary research · 2026Article
- Nutrition Research in Aging Dogs and Cats: What We Know and What We Need to Do.Animals : an open access journal from MDPI · 2026Review
- Longer duration of intact hypothalamic-pituitary-gonadal (HPG) axis buffers the adverse impact of late-life frailty in male dogs.Scientific reports · 2025Article
- Applying a life course approach to elucidate the biology of sex differences in frailty: early-life gonadectomy diminishes late-life robustness in male and female dogs in the Exceptional Aging in Rottweilers Study.Biology of sex differences · 2025Article
- Translational immune and metabolic markers of aging in dogs.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Declining metabolic function with aging is a conserved phenotype across many species. While aging-associated changes in metabolic status have been investigated rigorously in humans, less is known about metabolic aging in dogs. In this cross-sectional study, we aimed to examine changes in metabolic health with age, and any associations with frailty and quality of life, in a diverse population of companion dogs. This cross-sectional study enrolled 451 mature, adult companion dogs. Serum adiponectin, ALP, ALT, AST, cholesterol, insulin, IGF-1 and glucose levels were quantified. Additionally, plasma FFA, SFA, PA, OA and LA were quantified in a 61 dog subpopulation. All analytes were significantly associated with age, with the exception of AST. Elevated ALP, ALT, cholesterol, insulin, FFA, PA and OA were correlated with increased frailty scores, while higher levels of glucose and adiponectin were correlated with reduced frailty scores. The strength of these associations increased with age. Higher ALP, ALT and insulin were associated with lower HRQL scores after adjusting for covariates. Our findings establish novel associations between deleterious aging-associated metabolic changes and validated measures of clinical well-being in companion dogs. Future research should investigate the causality of these associations to inform therapeutic strategies targeting age-associated changes to frailty and quality of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.