Evidence map›Paper›PMID 39949253›Full record

ArticleJournal of medical virology2025

Tumor Necrosis Factor-Alpha Inhibits the Replication of Patient-Derived Archetype BK Polyomavirus While Activating Rearranged Strains.

Lise Lauterbach-Rivière, Lucia Thuringer, Pascal Feld, Lina Kathrin Toews, Jessica Schüssler, Jonas Klinz, Lars Gläser, Stefan Lohse, Anna Sternjakob, Gilles Gasparoni and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Lise Lauterbach-RivièreInstitute of Virology, Saarland University Medical Center, Homburg, Germany.ORCID 0000-0001-6705-3439
Lucia ThuringerInstitute of Virology, Saarland University Medical Center, Homburg, Germany.
Pascal FeldInstitute of Virology, Saarland University Medical Center, Homburg, Germany.
Lina Kathrin ToewsInstitute of Virology, Saarland University Medical Center, Homburg, Germany.
Jessica SchüsslerInstitute of Virology, Saarland University Medical Center, Homburg, Germany.
Jonas KlinzInstitute of Virology, Saarland University Medical Center, Homburg, Germany.
Lars GläserInstitute of Virology, Saarland University Medical Center, Homburg, Germany.
Stefan LohseInstitute of Virology, Saarland University Medical Center, Homburg, Germany.
Anna SternjakobInstitute of Virology, Saarland University Medical Center, Homburg, Germany.
Gilles GasparoniDepartment of Genetics, Saarland University, Saarbrücken, Germany.
Kathrin Kattler-LackesDepartment of Genetics, Saarland University, Saarbrücken, Germany.
Jörn WalterDepartment of Genetics, Saarland University, Saarbrücken, Germany.
Marcel A LauterbachMolecular Imaging, Center for Integrative Physiology and Molecular Medicine, Saarland University, Homburg, Germany.
Sven RahmannAlgorithmic Bioinformatics, Center for Bioinformatics Saar, Saarland Informatics Campus, Saarland University, Saarbrücken, Germany.
Lars MöllerAdvanced Light and Electron Microscopy, Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany.
Michael LaueAdvanced Light and Electron Microscopy, Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germany.
Martin JanssenDepartment of Urology, Saarland University Medical Center, Homburg, Germany.
Michael StöckleDepartment of Urology, Saarland University Medical Center, Homburg, Germany.
David SchmitDepartment of Nephrology, Saarland University Medical Center, Homburg, Germany.
Danilo FliserDepartment of Nephrology, Saarland University Medical Center, Homburg, Germany.
Sigrun SmolaInstitute of Virology, Saarland University Medical Center, Homburg, Germany.

Funding

This work was supported by the VolkswagenStiftung, grant 9B789, the Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS)/Helmholtz Centre for Infection Research (HZI) to Sigrun Smola, the Federal Ministry for Education and Research, XplOit, grant 031L0027B to Sigrun Smola, and the HOMFOR2020 program of the Medical Faculty of Saarland University to Lise Lauterbach-Rivière.
6 · The paper itself

Abstract

To date, no drugs are approved for BK polyomavirus (BKPyV) reactivation, a major cause of nephropathy after kidney transplantation. Recently, tumor necrosis factor-α (TNF-α) blockade has been proposed as a promising therapy, however, the effect of TNF-α on the clinically most common archetype (ww) BKPyV remained unclear. Assays in primary renal proximal tubule epithelial cells (RPTEC) allowed efficient replication only of BKPyV strains with rearranged (rr) non-coding control regions (NCCR), which may develop at later disease stages, but not of ww-BKPyV. Here, we optimized culture conditions allowing robust replication of patient-derived ww-BKPyV, while efficiently preserving their ww-NCCR. TNF-α promoted rr-BKPyV replication, while the T

Indexed as

BK VirusPolyomavirus InfectionsTumor Necrosis Factor-alphaVirus ReplicationCells, CulturedEpithelial CellsHumansInterferon-gammaVirus ActivationInterferon-gammaTumor Necrosis Factor-alphaantiviral therapyarchetypeBK polyomavirus (BKPyV)drug discoveryIFN‐γnon‐coding control region (NCCR)TNF‐α

Identifiers

PMID39949253
PMCPMC11826303

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.