Evidence map›Paper›PMID 39949767›Full record

ArticleFrontiers in immunology2025

Deciphering the functional roles of PE18 and PPE26 proteins in modulating

Aquib Ehtram, Mohd Shariq, Neha Quadir, Salma Jamal, Manjunath Pichipalli, Sheeba Zarin, Javaid Ahmad Sheikh, Nasreen Z Ehtesham, Seyed E Hasnain

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Protein-Mediated Virulence in Mycobacterium tuberculosis.Advances in experimental medicine and biology · 2026
    Review
  3. The PE/PPE family proteins ofFrontiers in immunology · 2025
    Review
  4. Pathological and immune features of non-tuberculous mycobacteria andFrontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aquib EhtramKusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi, India.
Mohd ShariqGITAM School of Science, Gandhi Institute of Technology and Management (GITAM) University, Hyderabad, Telangana, India.
Neha QuadirInflammation Biology and Cell Signaling Laboratory, ICMR-National Institute of Pathology, New Delhi, India.
Salma JamalJamia Hamdard Institute of Molecular Medicine, Jamia Hamdard, New Delhi, India.
Manjunath PichipalliInflammation Biology and Cell Signaling Laboratory, ICMR-National Institute of Pathology, New Delhi, India.
Sheeba ZarinJamia Hamdard Institute of Molecular Medicine, Jamia Hamdard, New Delhi, India.
Javaid Ahmad SheikhDepartment of Biotechnology, Jamia Hamdard, New Delhi, India.
Nasreen Z EhteshamDepartment of Life Science, School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India.
Seyed E HasnainDepartment of Life Science, School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India.

Funding

Comparison of Exhaled and Serum Nitric Oxide LevelsF31NR009457 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHOI, JIYEON · 2005 to 2008
$105k
NINR NIH HHS F31 NR009457
6 · The paper itself

Abstract

Introduction: Tuberculosis (TB), caused by Methods: We explored the roles of PE18 and PPE26 using recombinant Results: Our biochemical analyses confirmed interactions between PE18/PPE26, PE18/PPE27, PE19/PPE25, and EspG5/PPE, highlighting their involvement in ESX-5-mediated secretion. Cell fractionation studies revealed that PE/PPE proteins predominantly localize to the cell wall, with PE18 also secreted extracellularly. In vitro and Discussion: Our findings elucidate the pivotal roles of PE18 and PPE26 in

Indexed as

Antigens, BacterialBacterial ProteinsMycobacterium tuberculosisTuberculosisAnimalsHost-Pathogen InteractionsHumansMacrophagesMiceMice, Inbred C57BLMice, KnockoutMycobacterium smegmatisToll-Like Receptor 2Antigens, BacterialBacterial ProteinsToll-Like Receptor 2host-pathogen interactionIL-1 betaIL-6immune modulationmacrophage activation markerphagosomeproinflammatory cytokineTh1 immune response

Identifiers

PMID39949767
PMCPMC11821933

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.