Evidence map›Paper›PMID 39950475›Full record

ReviewCurrent hypertension reviews2025

The Combined Effect of Smoking and Obesity on Hypertension: Implications for Clinical Management.

Dimitrios Aragiannis, Alexandros Kasiakogias, Panagiotis Iliakis, Marios Sagris, Fotios Panagiotis Tatakis, Eleni Manta, Ioannis Andrikou, Dimitrios Konstantinidis, Konstantinos Tsioufis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Hypertension and vascular health in the young.Current opinion in pediatrics · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dimitrios AragiannisFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens Medical School, Greece.
Alexandros KasiakogiasFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens Medical School, Greece.
Panagiotis IliakisFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens Medical School, Greece.
Marios SagrisFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens Medical School, Greece.
Fotios Panagiotis TatakisFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens Medical School, Greece.
Eleni MantaFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens Medical School, Greece.
Ioannis AndrikouFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens Medical School, Greece.
Dimitrios KonstantinidisFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens Medical School, Greece.
Konstantinos TsioufisFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens Medical School, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A significant proportion of hypertensive patients are both smokers and obese. Several pathophysiological mechanisms are involved in the combined effect of smoking and obesity on hypertension onset and maintenance. These include increased sympathetic nervous system activity, endothelial dysfunction, inflammation, oxidative stress, and insulin resistance. The presence of these major cardiovascular risk factors may lead to difficult-to-control hypertension as well as substantially increase the risk for an adverse cardiovascular outcome. It is, therefore, imperative that healthcare providers embrace a comprehensive, multifaceted approach in the management of obese hypertensive patients with smoking habits. This review delves into the complex interplay of these risk factors, providing a comprehensive overview of the current literature to aid the deployment of effective clinical management strategies toward reducing the risk profile of affected individuals.

Indexed as

Blood PressureHypertensionObesitySmokingAntihypertensive AgentsHumansInsulin ResistanceRisk FactorsSmoking CessationSympathetic Nervous SystemAntihypertensive Agentscombined effectHypertensionobesityoxidative stress.smokingtobacco

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.