Evidence map›Paper›PMID 39950870›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and the HIF-1 Pathway in Polycystic Ovary Syndrome.

Guiquan Wang, Weian Mao, Yurong Zhang, Haiyan Yang, Ming Zhu, Yan Li, Wei Chen, Yi Chen, Chen Lou, Ping Li and 4 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guiquan WangDepartment of Reproductive Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China.ORCID https://orcid.org/0000-0002-6434-1627
Weian MaoDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China.
Yurong ZhangState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, 100191, China.ORCID https://orcid.org/0000-0002-1695-6213
Haiyan YangReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Ming ZhuThe First School of Medicine, Wenzhou Medical University, Wenzhou, 325035, China.
Yan LiReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Wei ChenReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yi ChenThe First School of Medicine, Wenzhou Medical University, Wenzhou, 325035, China.
Chen LouThe First School of Medicine, Wenzhou Medical University, Wenzhou, 325035, China.
Ping LiDepartment of Reproductive Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, 361003, China.
Hsun-Ming ChangDepartment of Obstetrics and Gynecology, China Medical University Hospital, Taichung, 40400, Taiwan.
Shuai YuanUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, 17177, Sweden.
Yue ZhaoState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, 100191, China.ORCID https://orcid.org/0000-0002-3016-9654
Liangshan MuReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.ORCID https://orcid.org/0000-0003-2498-3825

Funding

Key Clinical Projects of Peking University Third Hospital BYSY2022043National Key Research and Development Program of China 2021YFC2700402National Natural Science Foundation of China 82071608National Natural Science Foundation of China 82271665National Natural Science Foundation of China 82401908National Natural Science Foundation of China 82471670Pilot Project-China Reproductive Health Public Welfare Foundation SZ202414
6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) affects reproductive and cardiometabolic health, yet its pathogenesis remains unclear. Emerging evidence links hemoglobin levels to metabolic disorders, suggesting a potential role in PCOS development. Here, we integrated a large-scale cohort study, Mendelian randomization (A genetic tool to infer causal relationships), bioinformatics analyses, and in vitro experiments to investigate the relationship between hemoglobin levels and PCOS. In a cohort of 20 602 women, each 10 g L

Indexed as

HemoglobinsHypoxia-Inducible Factor 1Polycystic Ovary SyndromeAdultCohort StudiesFemaleHumansHypoxia-Inducible Factor 1, alpha SubunitMendelian Randomization AnalysisMultiomicsSignal TransductionTestosteroneHemoglobinsHIF1A protein, humanHypoxia-Inducible Factor 1Hypoxia-Inducible Factor 1, alpha SubunitTestosteronecausalityhemoglobinhyperandrogenismhypoxia‐inducible factorpolycystic ovary syndrome

Identifiers

PMID39950870
PMCPMC11984896

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.