Evidence map›Paper›PMID 39950996›Full record

ArticleDiabetes care2025

Arterial Stiffness Is Related to Diabetes-Associated Microvascular Complications: The SEARCH for Diabetes in Youth Study.

Ryan P Brady, Elaine M Urbina, Zhiqian Gao, Dana Dabelea, Eva Lustigova, Santica Marcovina, Amy K Mottl, Catherine Pihoker, Kristi Reynolds, LeAnne Sancrainte and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ryan P BradyDivision of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.ORCID 0000-0002-3087-4919
Elaine M UrbinaHeart Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
Zhiqian GaoHeart Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
Dana DabeleaLifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Denver, Aurora, CO.
Eva LustigovaDepartment of Research & Evaluation, Southern California Permanente Medical Group, Pasadena, CA.
Santica MarcovinaMedpace Reference Laboratories, Cincinnati, OH.
Amy K MottlDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Catherine PihokerDepartment of Pediatrics, University of Washington, Seattle, WA.
Kristi ReynoldsDepartment of Research & Evaluation, Southern California Permanente Medical Group, Pasadena, CA.
LeAnne SancrainteDivision of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
Lawrence M DolanDivision of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.
Amy S ShahDivision of Endocrinology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, OH.

Funding

UCHSC DIABETES ENDOCRINOLOGY RESEARCH CENTERP30DK057516 · UNIVERSITY OF COLORADO DENVER · 2000 to 2005
$7.4M
Molecular Epidemiology in Children's Environmental Health Training Program (MECEH)T32ES010957 · UNIVERSITY OF CINCINNATI · 2001 to 2025
$2.2M
CDC HHS DP-15-002, DP-05-069, DP-10-001Cincinnati Children's Hospital Medical Center Arnold W Strauss AwardEPA EP-C-15-002HSRD VA HIR 10-001NCATS NIH HHS UL1 TR000062NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000154NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR001425NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01 DP000248NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01 DP000254NCCDPHP CDC HHS U18 DP002708NCCDPHP CDC HHS U18 DP002709NCCDPHP CDC HHS U18 DP002710NCCDPHP CDC HHS U18 DP002714NCCDPHP CDC HHS U18 DP006131NCCDPHP CDC HHS U18 DP006133NCCDPHP CDC HHS U18 DP006134NCCDPHP CDC HHS U18 DP006136NCCDPHP CDC HHS U18 DP006138NCCDPHP CDC HHS U18 DP006139NIDDK NIH HHS 1R01DK127208-01,1UC4DK108173NIDDK NIH HHS P30 DK057516NIDDK NIH HHS R01 DK127208NIDDK NIH HHS UC4 DK108173NIEHS NIH HHS T32 ES010957
6 · The paper itself

Abstract

objectiveTo assess the relationship between arterial stiffness, an early marker of macrovascular cardiovascular disease, and microvascular complications in adolescents and young adults with youth-onset diabetes. RESEARCH DESIGN AND

methodsThis study included 1,226 individuals (median age at initial visit 18 years; 58% female; 53% non-Hispanic White, 22% non-Hispanic Black, and 20% Hispanic) with youth-onset type 1 or type 2 diabetes from the SEARCH for Diabetes in Youth Study. Arterial stiffness measures included pulse wave velocity for carotid femoral, carotid radial, femoral foot, and augmentation index (AIx). Microvascular complications included microalbuminuria, peripheral neuropathy, and retinopathy. Participants were followed up once at ∼5 years.

resultsCross-sectionally, in type 1 diabetes, AIx was associated with higher odds of having any one microvascular complication (odds ratio [OR] 1.35; 95% CI 1.04-1.76), microalbuminuria (OR 2.76; 95% CI 1.78-4.39), neuropathy (OR 1.63; 95% CI 1.07-2.50), and retinopathy (OR 1.37; 95% CI 1.06-1.79). In type 2 diabetes, AIx was associated with higher odds of microalbuminuria (OR 2.05; 95% CI 1.04-4.33; all P < 0.05). In longitudinal analysis, in type 1 diabetes, a change in AIx was associated with the development of any one microvascular complication (OR 1.45; 95% CI 1.15-1.82), microalbuminuria (OR 5.42; 95% CI 1.98-14.80), neuropathy (OR 2.03; 95% CI 1.22-3.40), and retinopathy (OR 1.48; 95% CI 1.15-1.90). In type 2 diabetes, a change in AIx was associated with the development of microalbuminuria (OR 21.98; 95% CI 1.30-372.88; all P < 0.05).

conclusionsArterial stiffness is related to and predicts microvascular complications in youth-onset type 1 and type 2 diabetes.

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic AngiopathiesVascular StiffnessAdolescentAdultAlbuminuriaChildCross-Sectional StudiesFemaleHumansMalePulse Wave AnalysisYoung Adult

Identifiers

PMID39950996
PMCPMC11932818

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.