Evidence map›Paper›PMID 39951546›Full record

ArticleScience immunology2025

TRAF3 is critical for initial T follicular helper cell specification via coordination of the IL-6R/IL-2R-BCL6 signaling nexus.

Peng Shao, Regina M Antonetti, Tina Arkee, Emma L Hornick, Hai Hui Xue, Gail A Bishop, Noah S Butler

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Highlights of 2025: advances in germinal centers.Immunology and cell biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peng ShaoDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-8453-6480
Regina M AntonettiInterdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA, USA.
Tina ArkeeDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Emma L HornickDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-1355-0576
Hai Hui XueCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.ORCID 0000-0002-9163-7669
Gail A BishopDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-1291-5078
Noah S ButlerDepartment of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-1429-0796

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007260 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WU, LI · 1986 to 2023
$5.7M
Tcf/Lef-b-catenin in T cell identity and cancerR01AI112579 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2015 to 2026
$5.4M
Tcf/Lef and B-catenin pathway in follicular helper T cellsR01AI121080 · NIAID · UNIVERSITY OF IOWA · PI Hai-Hui Xue · 2016 to 2026
$4.6M
Regulation of Plasmodium-specific CD4+ T CellsR01AI127481 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Noah Sullivan Butler · 2016 to 2026
$3.8M
Development and function of CD4+ memory T cells during malariaR01AI125446 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Noah Sullivan Butler · 2016 to 2026
$3.7M
Mechanisms and consequences of extrafollicular B cell activation during malariaR01AI167058 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN · 2021 to 2025
$3.2M
Molecular regulation of T cell activation signals by TRAF3R01AI123107 · NIAID · UNIVERSITY OF IOWA · PI BISHOP, GAIL A. · 2016 to 2020
$1.9M
Full Spectrum Cell Sorter Flow CytometerS10OD034193 · OD · UNIVERSITY OF IOWA · PI BALLAS, ZUHAIR K. · 2023 to 2023
$526k
BLRD VA I01 BX005771BLRD VA IK6 BX005392NCI NIH HHS P30 CA086862NIAID NIH HHS R01 AI112579NIAID NIH HHS R01 AI121080NIAID NIH HHS R01 AI123107NIAID NIH HHS R01 AI125446NIAID NIH HHS R01 AI127481NIAID NIH HHS R01 AI167058NIAID NIH HHS T32 AI007260NIEHS NIH HHS P30 ES005605NIH HHS S10 OD034193
6 · The paper itself

Abstract

CD4

Indexed as

Proto-Oncogene Proteins c-bcl-6Receptors, Interleukin-6T Follicular Helper CellsTNF Receptor-Associated Factor 3AnimalsCell DifferentiationHumansMiceMice, Inbred C57BLMice, KnockoutSignal TransductionBcl6 protein, mouseProto-Oncogene Proteins c-bcl-6Receptors, Interleukin-6TNF Receptor-Associated Factor 3

Identifiers

PMID39951546
PMCPMC12315785

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.