ArticleThe journal of prevention of Alzheimer's disease2025
Association of dietary diversity, genetic susceptibility, and the risk of incident dementia: A prospective cohort study.
Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Relationship between dietary diversity and periodontitis: analysis of NHANES 2003-2014.Acta odontologica Scandinavica · 2026Article
- Article
- Dietary diversity modifies the association between household solid fuel use and sleep health in older adults.Frontiers in nutrition · 2026Article
- Refining the evidence linking dietary diversity, genetic susceptibility, and dementia.The journal of prevention of Alzheimer's disease · 2025Article
- Reply to Letter to the Editor: "Refining the evidence linking dietary diversity, genetic susceptibility, and dementia".The journal of prevention of Alzheimer's disease · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have revealed how single foods or nutrients affect dementia, but the evidence for a potential link between dietary diversity and dementia is inconsistent.
objectivesThis study aimed to evaluate the association between dietary diversity and the risk of incident dementia. DESIGN, SETTING AND
participantsThis prospective study included 104,572 white participants without dementia at baseline recruited between 2006 and 2010 from the UK Biobank. MEASUREMENTS: Dietary Diversity Score (DDS) was acquired through the Oxford WebQ's 24-hour dietary recall survey spanning from 2009 to 2012. Cox proportional hazards models were used to estimate the associations between DDS, diversity scores of food groups and the risk of incident dementia. Stratified analyses were subsequently conducted to assess the potential variations across different demographic, socioeconomic, and genetic risk groups.
resultsOver a median follow-up period of 10.44 years, 725 participants developed incident dementia. A higher DDS was associated with a lower risk of incident dementia (HR: 0.95; 95 % CI: 0.93-0.97). Stratified analyses revealed statistical significance in this association for individuals under 65 years old (HR: 0.95; 95 % CI: 0.92-0.98), and those with higher polygenic risk scores (PRS; HR: 0.92; 95 % CI: 0.89-0.95). Among five food groups, a higher diversity score for meat and protein alternatives was associated with a lower risk of dementia (HR: 0.92; 95 % CI: 0.86-0.99).
conclusionEnhancing dietary diversity reduces dementia risk, and is potentially influenced by genetic predisposition. Consuming a diverse range of foods may be an effective strategy against dementia.
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Registered trials
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