ArticleNature communications2025
Lysosomal NKG7 restrains mTORC1 activity to promote CD8
Abstract read
In one paragraph
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Longxue tongluo capsule enhances ischemic stroke recovery via microbiota-metabolite-gene interactions.Metabolic brain disease · 2026Article
- Dual action of pimozide through lysosome disruption and inhibition of STATs induces apoptosis in chronic lymphocytic leukemia (CLL).Blood advances · 2026Article
- Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells.PLoS pathogens · 2026Article
- Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways.Aging cell · 2026Review
- T-Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan-Cancer Characteristics, and Therapeutic Interventions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- PD-1 regulates latent effector differentiation of thymic cytotoxic CD8Nature communications · 2026Article
- Natural Killer Cell Granule Protein (NKG7) promotes the development of vaccine-induced anti-fungal Th1 cells.bioRxiv : the preprint server for biology · 2026Article
- Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB.The Biochemical journal · 2026Review
- Targeting organelle function in T cells for cancer immunotherapy.Nature reviews. Immunology · 2026Review
- Integrated Single-Cell Multi-Omics Analysis Reveals That a CD8International journal of molecular sciences · 2026Article
- Metabolic reprogramming in cancer: signaling pathways and therapeutic targets.Molecular cancer · 2026Review
- Photothermal therapy triggering organelle stress and metabolic reprogramming to potentiate antitumor immunity.Frontiers in immunology · 2026Review
- Integrated single-cell multi-omics profiling reveals a senescence-associated hematopoietic landscape and regulatory network in aging bone marrow.Biogerontology · 2025Article
- Proteomics Insights Into Lysosome Biogenesis and Maturation.Proteomics · 2025Review
- A Dual Role for NKG7 in T-cell Cytotoxicity and Longevity.Cancer immunology research · 2025Review
- Mitochondria and lysosomes in T cell immunometabolism.Trends in immunology · 2025Review
- You are what you eat: autophagy guides CD8Immunometabolism (Cobham, Surrey) · 2025Article
- Identification and experimental validation of ulcerative colitis-associated hub genes through integrated WGCNA and lysosomal autophagy analysis.Human genomics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Hyoungjun HamDivision of Oncology Research, Mayo Clinic, Rochester, MN, USA. ham.hyoungjun@mayo.edu.ORCID http://orcid.org/0000-0002-8669-6875
Jacob B HirdlerDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Daniel T BihnamDepartment of Immunology, Mayo Clinic, Phoenix, AZ, USA.ORCID http://orcid.org/0009-0006-2622-2324
Zhiming MaoDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-7705-9575
Joanina K GicobiDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Bruna Gois MacedoDepartment of Immunology, Mayo Clinic, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0001-6907-1630
Maria F Rodriguez-QuevedoDivision of Oncology Research, Mayo Clinic, Rochester, MN, USA.
Destiny F SchultzDivision of Oncology Research, Mayo Clinic, Rochester, MN, USA.
Cristina CorreiaDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-9464-7555
Jun ZhongDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-3148-4143
Kodi E MartinezDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Alma BanuelosDepartment of Immunology, Mayo Clinic, Phoenix, AZ, USA.
Dallin S AshtonDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Anthony B LagnadoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-9380-5179
Ruifeng GuoDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0003-3345-0502
Rodrigo PessoaDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9943-6127
Hu LiDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5957-5472
Fabrice LucienDepartment of Urology, Mayo Clinic, Rochester, MN, USA.
Henrique Borges da SilvaDepartment of Immunology, Mayo Clinic, Phoenix, AZ, USA.
Haidong DongDepartment of Urology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-5782-2983
Daniel D BilladeauDivision of Oncology Research, Mayo Clinic, Rochester, MN, USA. billadeau.daniel@mayo.edu.ORCID http://orcid.org/0000-0002-2296-9547
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MMSTP at Mayo Clinic RochesterT32GM145408 · NIGMS · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN, LISA A SCHIMMENTI · 2023 to 2026
$4.7MControl of antiviral memory CD8+ T cell longevity by extracellular ATP sensingR01AI170649 · NIAID · MAYO CLINIC ARIZONA · PI Henrique Borges da Silva · 2022 to 2026
$2.4MNCI NIH HHS P30 CA015083NIAID NIH HHS R01 AI170649NIGMS NIH HHS T32 GM145408
Abstract
During infection and cancer, mTORC1-mediated metabolic regulation impacts CD8
Indexed as
CD8-Positive T-LymphocytesLysosomesMechanistic Target of Rapamycin Complex 1NeoplasmsAnimalsFemaleHumansMiceMice, Inbred C57BLMice, KnockoutSignal TransductionVacuolar Proton-Translocating ATPasesMechanistic Target of Rapamycin Complex 1Vacuolar Proton-Translocating ATPases
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.