Evidence map›Paper›PMID 39953112›Full record

ArticleScientific reports2025

Tongue coating microbial communities vary in children with Henoch-Schönlein purpura.

Shuang Pang, Qinghao Yan, Qunfeng Lu, Wenjian Chen, Yan Dai, Liping Yue, Yan Xu, Min Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuang PangDepartment of Nursing, Institute of International Medical Science and Technology, Shanghai Sanda University, Shanghai, 201209, China.
Qinghao YanLonghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Qunfeng LuDepartment of Nephrology, Rheumatology and Immunology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Wenjian ChenDepartment of Nephrology, Rheumatology and Immunology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Yan DaiDepartment of Nephrology, Rheumatology and Immunology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China.
Liping YueDepartment of Nursing, Institute of International Medical Science and Technology, Shanghai Sanda University, Shanghai, 201209, China.
Yan XuDepartment of Nursing, Institute of International Medical Science and Technology, Shanghai Sanda University, Shanghai, 201209, China. xuyan1128@sina.com.
Min LiDepartment of Nursing, Institute of International Medical Science and Technology, Shanghai Sanda University, Shanghai, 201209, China. limin@smmu.edu.cn.

Funding

2022 Research Project of Shanghai Sanda University No. 2022BSZX04Shanghai Municipal Education Commission Professional Master's Degree Excellent Cultivation Research Project No. 2023PYZX20
6 · The paper itself

Abstract

Previous research has shown that microbes play a role in immune-related diseases. Our study reveals that children with Henoch-Schönlein purpura nephritis have distinct and altered tongue coating microbiota, characterized by significant changes in species richness, diversity, and specific microbial compositions compared with healthy controls. Nevertheless, the particular involvement of tongue coating microbiota in Henoch-Schönlein Purpura remains unclear. A total of 26 children were enrolled, including 13 patients with HSP and 13 healthy children. Tongue coating samples were collected for DNA extraction and 16S rRNA gene sequencing. Alpha diversity indices, including ACE, Chao1, Shannon, and Simpson indices, revealed significantly lower richness and diversity of tongue coating microbiota in children with Henoch-Schönlein purpura compared to healthy controls. Beta diversity analysis demonstrated distinct clustering of microbial communities between HSP and healthy children, with significant compositional differences. 16S rRNA gene sequencing showed that the relative abundance of key genera, such as Veillonella and Prevotella, differed between the two groups. A random forest algorithm identified five genera as potential diagnostic biomarkers for HSP. Co-occurrence analysis revealed different hub microbes in HSP and healthy children. BugBase predicted an increased proportion of stress-tolerant bacteria in the HSP group compared to the healthy controls group. PICRUSt analysis indicated alterations in metabolic functions of tongue coating microbiota between HSP and healthy children, with 25 KEGG pathways exhibiting significant differences. Children with HSP exhibit marked differences in their tongue coating microbiota when contrasted with their healthy counterparts.

Indexed as

IgA VasculitisMicrobiotaTongueBacteriaCase-Control StudiesChildChild, PreschoolFemaleHumansMaleRNA, Ribosomal, 16SRNA, Ribosomal, 16S16S rRNAChildrenHenoch-Schönlein purpuraMicrobiotaTongue coating

Identifiers

PMID39953112
PMCPMC11828920

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.