Evidence map›Paper›PMID 39953142›Full record

ArticleNPJ digital medicine2025

Identifying major depressive disorder in older adults through naturalistic driving behaviors and machine learning.

Chen Chen, David C Brown, Noor Al-Hammadi, Sayeh Bayat, Anne Dickerson, Brenda Vrkljan, Matthew Blake, Yiqi Zhu, Jean-Francois Trani, Eric J Lenze and 2 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chen ChenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
David C BrownDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Noor Al-HammadiDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Sayeh BayatDepartment of Biomedical Engineering, Schuluch School of Engineering, University of Calgary, Calgary, AB, Canada.
Anne DickersonDepartment of Occupational Therapy, East Carolina University, Greenville, NC, USA.
Brenda VrkljanOccupational Therapy, School of Rehabilitation Science, McMaster University, Hamilton, ON, Canada.
Matthew BlakeDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Yiqi ZhuDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Jean-Francois TraniBrown School, Washington University in St. Louis, St. Louis, MO, USA.
Eric J LenzeDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
David B CarrDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Ganesh M BabulalDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA. babulalg@wustl.edu.

Funding

Naturalistic driving as a functional neurobehavioral marker of preclinical and symptomatic Alzheimer diseaseR01AG068183 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2020 to 2024
$6.7M
Preclinical Alzheimer Disease and DrivingR01AG056466 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2017 to 2021
$5.9M
The Impact of Depression and Preclinical Alzheimer Disease on Driving Among Older AdultsR01AG067428 · NIA · WASHINGTON UNIVERSITY · PI BABULAL, GANESH M · 2020 to 2024
$4.0M
NIA NIH HHS R01 AG056466NIA NIH HHS R01 AG067428NIA NIH HHS R01 AG068183NIA NIH HHS R01AG068183
6 · The paper itself

Abstract

Depression in older adults is often underdiagnosed and has been linked to adverse outcomes, including motor vehicle crashes. With a growing population of older drivers in the United States, innovations in screening methods are needed to identify older adults at greatest risk of decline. This study used machine learning techniques to analyze real-world naturalistic driving data to identify depression status in older adults and examined whether specific demographics and medications improved model performance. We analyzed two years of GPS data from 157 older adults, including 81 with major depressive disorder, using XGBoost and logistic regression models. The top-performing model achieved an area under the curve of 0.86 with driving features combined with total medication use. These findings suggest that naturalistic driving data holds high potential as a functional digital neurobehavioral marker for AI identifying depression in older adults on a national scale, thereby ensuring equitable access to treatment.

Identifiers

PMID39953142
PMCPMC11828977

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.