Evidence map›Paper›PMID 39953756›Full record

ArticleCancer medicine2025

Delivering Trio Germline Whole Genome Sequencing to Patients Newly Diagnosed With Childhood Cancer: Healthcare Professionals' Perspectives of the PREDICT Study.

Jacqueline D Hunter, Kate Hetherington, Claire E Wakefield, Katherine M Tucker, Brittany C McGill, Andrew Grant, Noemi A Fuentes-Bolanos, Bhavna Padhye, Margaret Gleeson, Kanika Bhatia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jacqueline D HunterDepartment of Obstetrics, Gynaecology and Newborn Health, Royal Women's Hospital, Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.ORCID https://orcid.org/0000-0002-2051-0396
Kate HetheringtonSchool of Clinical Medicine, Randwick Clinical Campus, Discipline of Paediatrics and Child Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-5457-5462
Claire E WakefieldSchool of Clinical Medicine, Randwick Clinical Campus, Discipline of Paediatrics and Child Health, UNSW Sydney, Sydney, New South Wales, Australia.
Katherine M TuckerHereditary Cancer Centre, Department of Medical Oncology, Prince of Wales Hospital, Randwick, New South Wales, Australia.
Brittany C McGillSchool of Clinical Medicine, Randwick Clinical Campus, Discipline of Paediatrics and Child Health, UNSW Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-2134-2988
Andrew GrantKids Cancer Centre, Sydney Children's Hospital, Sydney, New South Wales, Australia.
Noemi A Fuentes-BolanosSchool of Clinical Medicine, Randwick Clinical Campus, Discipline of Paediatrics and Child Health, UNSW Sydney, Sydney, New South Wales, Australia.
Bhavna PadhyeCancer Centre for Children, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.ORCID https://orcid.org/0000-0003-0740-3606
Margaret GleesonChildren's Cancer and Haematology Service, John Hunter Children's Hospital, Newcastle, New South Wales, Australia.
Kanika BhatiaRoyal Children's Hospital, Melbourne, Victoria, Australia.
Michelle PeateDepartment of Obstetrics, Gynaecology and Newborn Health, Royal Women's Hospital, Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.

Funding

Australian Government Research and Training Program (RTP) ScholarshipCancer Institute NSW 2021/TPG2112Luminesce Alliance - Innovation for Children's HealthNational Health and Medical Research Council APP2008300The Kid's Cancer Project Col Reynolds PhD Top-Up Scholarship
6 · The paper itself

Abstract

backgroundGermline genomic sequencing (GS) is increasingly offered to children with cancer. To optimize integration into routine care, assessment of implementation barriers and a better understanding of healthcare professionals' perspectives and experiences are needed.

methodsHealthcare professionals delivered trio germline GS to newly diagnosed pediatric and adolescent patients with cancer via the PREDICT completed questionnaires with qualitative and quantitative items. Each study site recorded reasons for eligible families' nonenrolment in PREDICT to identify barriers to recruitment. Quantitative data were analyzed via descriptive statistics, whereas qualitative data underwent inductive content analysis, with results integrated for interpretation.

resultsThirty-three healthcare professionals participated, including 23 oncology professionals and 10 genetic professionals. Healthcare professionals perceived PREDICT as beneficial to participating and future families, and that perceptions of personal benefit and altruism were drivers of family uptake. Concerns included workforce capacity and potential family distress given the trio design and high-stress diagnosis setting. Barriers to recruitment related to clinical decision-making, family factors, and logistics. Although most rated their genetics/genomics knowledge as "good," regarding germline results, few were "very confident" interpreting (29%), explaining (32%), making treatment recommendations (9.7%), and providing psychosocial support to families (29%). They acknowledged a need for further training in these areas for trainees; yet, fewer were interested in training for themselves.

conclusionSuccessful implementation of routine germline GS will require targeted strategies to address logistical issues and alleviate potential negative psychosocial impacts for families. Recognizing the escalating demand on genetics experts, upskilling of the current workforce and involvement of a broader spectrum of healthcare professionals are warranted.

Indexed as

Attitude of Health PersonnelGerm-Line MutationHealth PersonnelNeoplasmsWhole Genome SequencingAdolescentAdultChildFemaleGenetic TestingHumansMaleSurveys and Questionnairescancer geneticsgenome wide sequencinghereditary cancerpediatric cancer

Identifiers

PMID39953756
PMCPMC11829071

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.