Evidence map›Paper›PMID 39956708›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

The thalamus: Structure, function, and neurotherapeutics.

Lara V Marcuse, Mackenzie Langan, Patrick R Hof, Fedor Panov, Igancio Saez, Joohi Jimenez-Shahed, Martijn Figee, Helen Mayberg, Ji Yeoun Yoo, Saadi Ghatan and 2 more

Erratum issuedAbstract readReview
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Thalamic Nuclei Atrophy in Type 1 Diabetes Mellitus Across Disease Duration.Journal of magnetic resonance imaging : JMRI · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Lara V MarcuseDepartment of Neurology, Epilepsy Division, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1000 10th Ave, New York, NY 10019, USA. Electronic address: Lara.marcuse@mssm.edu.
Mackenzie LanganBioMedical Engineering and Imaging Institute (BMEII), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029, USA.
Patrick R HofNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 787 11th Avenue New York, NY 10019, USA.
Fedor PanovDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, 1000 10th Ave, New York, NY 10019, USA.
Igancio SaezDepartment of Neurology, Epilepsy Division, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1000 10th Ave, New York, NY 10019, USA; Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, 787 11th Avenue New York, NY 10019, USA; Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, 1000 10th Ave, New York, NY 10019, USA; Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1000 10th Ave, New York, NY 10019, USA.
Joohi Jimenez-ShahedDepartment of Neurology, Movement Disorders Division, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1000 10th Ave, New York, NY 10019, USA.
Martijn FigeeDepartment of Neurology, Movement Disorders Division, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1000 10th Ave, New York, NY 10019, USA.
Helen MaybergNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1000 10th Ave, New York, NY 10019, USA.
Ji Yeoun YooDepartment of Neurology, Epilepsy Division, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1000 10th Ave, New York, NY 10019, USA.
Saadi GhatanDepartment of Neurosurgery, Icahn School of Medicine at Mount Sinai, 1000 10th Ave, New York, NY 10019, USA.
Priti BalchandaniBioMedical Engineering and Imaging Institute (BMEII), Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029, USA.
Madeline C FieldsDepartment of Neurology, Epilepsy Division, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1000 10th Ave, New York, NY 10019, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complexity and expansive nature of thalamic research has led to numerous interventions for varied disease states. At the same time, this complexity along with siloed areas of study can hinder a comprehensive understanding. The goal of this paper is to give the reader a broader and more detailed perspective on the thalamus. In order to accomplish this goal, the paper begins with a summary of the function, electrophysiology, and anatomy of the normal thalamus. With this foundation, thalamic involvement in neurological diseases is discussed with a focus on epilepsy. Therapeutic interventions in the thalamus for epilepsy as well as movement disorders, psychiatric conditions and disorders of consciousness are described. Lastly limitations in the field and future models of data sharing and cooperation are explored.

Indexed as

ThalamusAnimalsEpilepsyHumansComaDrug-resistant epilepsyNeuromodulationThalamusTourette's syndromeTremor

Identifiers

PMID39956708
PMCPMC12014413

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.