Evidence map›Paper›PMID 39956864›Full record

ArticleOncogene2025

The splicing factor SRRM2 modulates two S6K kinases to promote colorectal cancer growth.

Zhengwei Yan, Luling He, Jiawei Yuan, Yulong Niu, Shimin Shuai, Shiwen Luo, Changzheng Du, Hai Rao

Abstract read
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In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhengwei Yan *Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Luling He *Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Jiawei YuanDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Yulong NiuDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Shimin ShuaiDepartment of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.ORCID http://orcid.org/0000-0002-9527-8018
Shiwen LuoSchool of Medicine, Nanchang University, Nanchang, Jiangxi, China.ORCID http://orcid.org/0000-0002-8267-7685
Changzheng DuDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Hai RaoDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, China. raoh@sustech.edu.cn.ORCID http://orcid.org/0000-0002-4235-2210

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82170159
6 · The paper itself

Abstract

The mechanistic target of rapamycin (mTOR) pathway plays a critical role in cell growth and metabolic homeostasis. The ribosomal protein S6 kinases S6K1 and S6K2 are the major effectors of the mTOR pathway key to translation efficiency, but the underlying regulatory mechanisms remain largely unclear. In this study, we searched for mTOR regulators and found that the splicing factor SRRM2 modulates the levels of S6K1 and S6K2, thereby activating the mTOR-S6K pathway. Interestingly, SRRM2 facilitates the expression of S6K2 by modulating alternative splicing, and enhances the stability of the S6K1 protein by regulating the E3 ubiquitin ligase WWP2. Moreover, SRRM2 is highly expressed in colorectal cancer (CRC) tissues and is associated with a poor prognosis. SRRM2 promotes CRC growth in vitro and in vivo. Combined, these data reveal an oncogenic role of SRRM2 in CRC through activating the mTOR-S6K pathway by two different approaches, further suggesting SRRM2 as a potential therapeutic target for CRC.

Indexed as

Colorectal NeoplasmsRibosomal Protein S6 Kinases, 70-kDaRNA-Binding ProteinsRNA Splicing FactorsAlternative SplicingAnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMiceMice, NudeSignal TransductionTOR Serine-Threonine KinasesUbiquitin-Protein LigasesMTOR protein, humanribosomal protein S6 kinase, 70kD, polypeptide 1ribosomal protein S6 kinase, 70kD, polypeptide 2Ribosomal Protein S6 Kinases, 70-kDaRNA-Binding ProteinsRNA Splicing FactorsTOR Serine-Threonine KinasesUbiquitin-Protein Ligases

Identifiers

PMID39956864

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.