Evidence map›Paper›PMID 39957237›Full record

ReviewHuman vaccines & immunotherapeutics2025

Mini-review on the therapeutic vaccines targeting chronic infectious diseases: Evaluation system of therapeutic vaccines targeting HPV and EBV-related cancers.

Seungkyun Woo, Pil-Gu Park, Timothy An, Munazza Fatima, Ye-Eun Moon, Seok-Yong Lee, Hyewon Youn, Kee-Jong Hong

Abstract readReview
In one paragraph

Review in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Nasal vaccination againstFrontiers in immunology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Seungkyun WooDepartment of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Korea.
Pil-Gu ParkDepartment of Microbiology, Gachon University College of Medicine, Incheon, Korea.
Timothy AnLee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea.
Munazza FatimaDepartment of Microbiology, Gachon University College of Medicine, Incheon, Korea.
Ye-Eun MoonDepartment of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Korea.
Seok-Yong LeeDepartment of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul, Korea.
Hyewon YounDepartment of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul, Korea.
Kee-Jong HongDepartment of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Korea.ORCID 0000-0003-2054-7014

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic infectious diseases are threatening human health today, and their public health severity is increasing. The efficacy issues of drugs and the increase in drug-resistant pathogens require new response strategies for chronic infectious diseases, and therapeutic vaccines have recently been proposed as an effective alternative. However, research on therapeutic vaccines is still relatively underdeveloped. To solve this problem, an accurate understanding of the status and the challenge at hand of therapeutic vaccines targeting chronic infectious diseases is needed. In the present review, we provide an overview of the latest research trends in therapeutic vaccines targeting chronic infectious diseases and summarize the development status of therapeutic vaccines currently undergoing clinical research, focusing on the cases of human papillomavirus (HPV) and Epstein-Barr virus (EBV) as representative examples. We highlight the importance of standard methods for the evaluation of therapeutic vaccine, focusing on the cell-mediated immune response, which might accelerate therapeutic vaccine development.

Indexed as

Cancer VaccinesEpstein-Barr Virus InfectionsNeoplasmsPapillomavirus InfectionsPapillomavirus VaccinesViral VaccinesAnimalsChronic DiseaseHerpesvirus 4, HumanHumansImmunity, CellularVaccine DevelopmentCancer VaccinesPapillomavirus VaccinesViral Vaccinescell-mediated immunity (CMI)Chronic infectious diseaseEpstein-Barr Virus (EBV)human papillomavirus (HPV)therapeutic vaccine

Identifiers

PMID39957237
PMCPMC11834422

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.