Evidence map›Paper›PMID 39957498›Full record

ArticlePsychological medicine2025

Impulsivity facets and substance use involvement: insights from genomic structural equation modeling.

Laura Vilar-Ribó, Alexander S Hatoum, Andrew D Grotzinger, Travis T Mallard, 23andMe Research Team, Sarah Elson, Pierre Fontanillas, Abraham A Palmer, Daniel E Gustavson, Sandra Sanchez-Roige

Abstract read
In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The Genoeconomics of Impulsive Intertemporal Choice: A Critical Review.Journal of the experimental analysis of behavior · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura Vilar-RibóDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-8758-523X
Alexander S HatoumDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-8002-7267
Andrew D GrotzingerInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0001-7852-9244
Travis T MallardPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-3265-3001
23andMe Research Team
Sarah Elson23andMe, Inc., Sunnyvale, CA, USA.ORCID 0000-0002-3211-3750
Pierre Fontanillas23andMe, Inc., Sunnyvale, CA, USA.ORCID 0000-0002-8944-4454
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-3634-0747
Daniel E GustavsonInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.ORCID 0000-0002-1470-4928
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-6137-5699

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI CHEN, HAO · 2014 to 2023
$27.4M
DP30DA060810 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Abraham A Palmer · 2024 to 2026
$5.6M
Interdisciplinary Research Fellowship in NeuroAIDSR25MH081482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARIANA CHERNER · 2007 to 2026
$5.2M
Dissecting the Multivariate Genetic Architecture of Psychiatric DiseasesR01MH120219 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI NIVARD, MICHEL GUILLAUME, TUCKER-DROB, ELLIOT MAX · 2020 to 2024
$3.3M
Building Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4M
Establishing if Music Engagement is a Protective Factor in Adolescent Substance Use Using Existing Longitudinal, Genetic, and Environmental DatasetsR01DA059804 · NIDA · UNIVERSITY OF COLORADO · PI Daniel Gustavson · 2024 to 2026
$2.0M
Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic ApproachesK01AA030083 · NIAAA · WASHINGTON UNIVERSITY · PI Alexander S Hatoum · 2022 to 2026
$897k
Understanding developmental neurogenomic mechanisms in externalizing disordersK08MH135343 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Travis T Mallard · 2024 to 2026
$588k
NIAAA NIH HHS AA030083NIAAA NIH HHS K01 AA030083NIDA NIH HHS DP1 DA054394NIDA NIH HHS P30 DA060810NIDA NIH HHS P50 DA037844NIDA NIH HHS R01 DA059804NIMH NIH HHS K08 MH135343NIMH NIH HHS R01 MH120219NIMH NIH HHS R01MH120219NIMH NIH HHS R25 MH081482Tobacco-Related Disease Research Program 28IR-0070
6 · The paper itself

Abstract

backgroundImpulsivity is a multidimensional trait associated with substance use disorders (SUDs), but the relationship between distinct impulsivity facets and stages of substance use involvement remains unclear.

methodsWe used genomic structural equation modeling and genome-wide association studies (

resultsWe found that the SU and SUD factors were strongly genetically inter-correlated (

conclusionsOur findings show that specific impulsivity facets confer risk for distinct stages of substance use involvement, with potential implications for SUDs prevention and treatment.

Indexed as

Impulsive BehaviorSubstance-Related DisordersAdolescentAdultFemaleGenome-Wide Association StudyHumansLatent Class AnalysisMaleMiddle AgedYoung Adultaddictiongenomic structural equation modelingGWASimpulsivitysubstance use

Identifiers

PMID39957498
PMCPMC12039315

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.