Evidence map›Paper›PMID 39957761›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2025

Short-term exposure to relative humidity and lung health in early adolescents.

Nicholas J Nassikas, Wenli Ni, Sheryl L Rifas-Shiman, Heike Luttmann-Gibson, Andrew Synn, Emily Oken, Diane R Gold, Mary B Rice

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas J NassikasDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.ORCID https://orcid.org/0000-0002-0798-3703
Wenli NiDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
Heike Luttmann-GibsonDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Andrew SynnDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts.
Diane R GoldDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Mary B RiceDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
Climate Variability and Respiratory Health in Asthma and COPDK23ES035863 · NIEHS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Nicholas Nassikas · 2024 to 2026
$769k
NICHD NIH HHS R01 HD034568NIEHS NIH HHS K23 ES035863NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R24 ES030894
6 · The paper itself

Abstract

Background: Extremes in humidity can induce bronchoconstriction and trigger breathing symptoms in people with asthma. Less is known about how humidity influences measurements of lung health in children and adolescents. Our objective was to assess the extent to which short-term exposures to high and low relative humidity (RH) are associated with lung function and fractional exhaled nitric oxide (FeNO) in adolescents. Methods: We included adolescents (mean age 13.2 y, SD: 0.9) from a northeast US prospective prebirth cohort (n = 1019). We assigned daily RH levels to geocoded participant addresses. We defined low or high RH as ≤10 Results: Median RH was 65.6% (interquartile range [IQR] = 19.8%), 10th percentile 47.2%, 90th percentile 86.6%. Mean FeNO (SD) was 25.9ppb (26.9ppb). High (vs. median) RH was associated with 38.0% higher FeNO (95% CI = 10.3, 72.7). Exposure to low (vs. median) RH was associated with 186.2 ml lower FEV Conclusion: Short-term exposures to extremes of RH were associated with lower lung function and higher FeNO, a measure of airway inflammation, in adolescents.

Indexed as

ChildrenClimate changeFractional exhaled nitric oxideLung functionSpirometry

Identifiers

PMID39957761
PMCPMC11822341

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.