ArticleBiomedical optics express2025
Challenging the skin pigmentation bias in tissue oximetry via time-domain near-infrared spectroscopy.
Article in Biomedical optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Distinguishing Muscle Oxygen Saturation from Tissue Oxygen Saturation: Accuracy, Limitations, and Practical Utility in Muscle Oximetry.Sports medicine - open · 2026Article
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Temperature-induced hemoglobin dynamics: oxygenation-dependent evolution of hemoglobin spectral response in the near-infrared.Biophotonics discovery · 2026Article
- In-vivo optical properties spectra across five body locations on ten subjects using time-domain diffuse optics.Scientific data · 2026Article
- Quantifying the impact of hair and skin characteristics on fNIRS signal quality for enhanced inclusivity.Nature human behaviour · 2025Article
- Quantitative analysis of tissue oxygenation variability across anatomical landmarks in healthy individuals via near-infrared spectroscopy.Scientific reports · 2025Article
- Towards the use of functional near-infrared spectroscopy as an assessment tool in disorders of consciousness.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, skin pigmentation has been shown to affect the performance of pulse oximeters and other light-based techniques like photo-acoustic imaging, tissue oximetry, and continuous wave near-infrared spectroscopy. Evaluating the robustness to changes in skin pigmentation is therefore essential for the proper use of optical technologies in the clinical scenario. We conducted systematic time-domain near-infrared spectroscopy measurements on calibrated tissue phantoms and in vivo on volunteers during static and dynamic (i.e., arterial occlusion) measurements. To simulate varying melanosome volume fractions in the skin, we inserted, between the target sample and the measurement probe, thin tissue phantoms made of silicone and nigrosine (skin phantoms). Additionally, we conducted an extensive measurement campaign on a large cohort of pediatric subjects, covering the full spectrum of skin pigmentation. Our findings consistently demonstrate that skin pigmentation has a negligible effect on time-domain near-infrared spectroscopy results, underscoring the reliability and potential of this emerging technology in diverse clinical settings.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.