ArticleJournal of conservative dentistry and endodontics2024
Comparison of double antibiotic chitosan hydrogel scaffold with platelet-rich fibrin in regeneration in immature necrotic permanent teeth - Randomized controlled trial.
Article in Journal of conservative dentistry and endodontics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Context-dependent effectiveness of autologous platelet concentrates in regenerative endodontic procedures and periapical surgery: A systematic review and meta-analysis.Journal of conservative dentistry and endodontics · 2026Review
- Partial radicular versus coronal pulpotomy using chitosan and platelet-rich fibrin in vital permanent molars with irreversible pulpitis, with or without associated apical periodontitis: A randomized controlled trial.Journal of conservative dentistry and endodontics · 2026Article
- Regenerative endodontics: current concepts, clinical challenges, and emerging therapies.Brazilian oral research · 2026Review
- Revascularizing ability of platelet-rich fibrin in permanent necrotic immature teeth: A systematic review and meta-analysis.Journal of conservative dentistry and endodontics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Fibrin, a natural hydrogel, can act as scaffold for tissue regeneration. Antibiotic-loading of hydrogels can create an infection-free environment for stem cell proliferation and maturation. Aim: To compare regenerative endodontic potential of three groups (antibiotic-loaded hydrogel, chitosan-loaded hydrogel, and double antibiotic-loaded chitosan hydrogel) in immature necrotic permanent teeth with platelet rich fibrin (PRF). Materials and Methods: Fifty-six immature necrotic teeth with periapical lesions were included in simple randomized parallel-controlled superiority trial. Patients aged 10-35 years were assigned into four groups based on scaffolds used: Group 1 (PRF), Group 2 (double antibiotic-loaded [metronidazole and ciprofloxacin] chitosan hydrogel), Group 3 (double antibiotic-loaded hydrogel), and Group 4 (chitosan-loaded hydrogel). One patient per group was lost to follow-up. Regenerative outcomes (change in apex size, root length, radicular dentin thickness, and periapical healing) were assessed at 12 months, through double-blinding and compared postprocedure using cone-beam computed tomography. Statistical Analysis: Based on normality distribution, change in apex size (ANOVA test) while root length, radicular dentin thickness (Kruskal-Wallis test), and periapical healing (paired Results: Group 2 showed superior regenerative outcomes ( Conclusion: Double antibiotic-loaded chitosan produced significantly superior outcomes compared to PRF in promoting apexogenesis in immature permanent teeth with necrosed pulp.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.