Evidence mapPaperPMID 39959999Full record

ArticleJournal of the American Chemical Society2025

Chemical Synthesis Reveals Pathogenic Role of

Wyatt C Powell, Ruiheng Jing, Morgane Herlory, Patrick Holland, Darya Poliyenko, Christopher C Ebmeier, Michael H B Stowell, Maciej A Walczak

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Revealing the Biological Effect of theJournal of the American Chemical Society · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wyatt C PowellDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
Ruiheng JingDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.ORCID 0009-0002-1261-5902
Morgane HerloryDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
Patrick HollandDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.
Darya PoliyenkoDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, United States.
Christopher C EbmeierProteomics and Mass Spectrometry Core Facility, Department of Biochemistry, University of Colorado, Boulder, Colorado 80303, United States.
Michael H B StowellDepartment of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, United States.
Maciej A WalczakDepartment of Chemistry, University of Colorado, Boulder, Colorado 80309, United States.ORCID 0000-0002-8049-0817

Funding

Non-enzymatic post-translational modifications as drivers of AD pathologyR01AG087295 · UNIVERSITY OF COLORADO · 2025 to 2025
$722k
Interdisciplinary Predoctoral Training in Molecular BiophysicsT32GM145437 · UNIVERSITY OF COLORADO · 2025 to 2025
$549k
NCRR NIH HHS S10 RR026680NCRR NIH HHS S10 RR028036NIA NIH HHS R01 AG087295NIA NIH HHS RF1 AG079294NIGMS NIH HHS R21 GM138808NIGMS NIH HHS T32 GM145437
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of tau protein aggregates. In this study, we investigated the effects of

Indexed as

tau ProteinsAlzheimer DiseaseGlycosylationHumansPhosphorylationPolysaccharidesPolysaccharidestau Proteins

Identifiers

PMID39959999
PMCPMC11892074

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.