Evidence map›Paper›PMID 39960339›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function.

Zeinabou Niasse-Sy, Bo Zhao, Ajda Lenardič, Huyen Thuc Tran Luong, Ori Bar-Nur, Johan Auwerx, Martin Wohlwend

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zeinabou Niasse-SyLaboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland.
Bo ZhaoMassachusetts Institute of Technology (MIT), Cambridge, 02139, USA.
Ajda LenardičLaboratory of Regenerative and Muscle Biology, Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zurich, Schwerzenbach, 8603, Switzerland.
Huyen Thuc Tran LuongLaboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland.
Ori Bar-NurLaboratory of Regenerative and Muscle Biology, Institute of Human Movement Sciences and Sport, Department of Health Sciences and Technology, ETH Zurich, Schwerzenbach, 8603, Switzerland.
Johan AuwerxLaboratory of Integrative Systems Physiology, École polytechnique fédérale de Lausanne (EPFL), Lausanne, 1015, Switzerland.
Martin WohlwendMassachusetts Institute of Technology (MIT), Cambridge, 02139, USA.ORCID https://orcid.org/0000-0001-9851-0364

Funding

European Research Council ERC-AdG-787702Fondation Suisse de Recherche sur les Maladies Musculaires (FSRMM)
6 · The paper itself

Abstract

Fast twitch muscle fibers are prone to degradation in skeletal muscle pathologies, such as sarcopenia and muscular dystrophies. We previously showed that the exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis. Here, we identify an independent functional element within human CYTOR, and optimize its RNA delivery. In human primary myoblasts exogenous CYTOR exon 2 recapitulates the effect of full-length CYTOR by boosting fast-twitch myogenic differentiation. Furthermore, chemically modified CYTOR exon 2 RNA

Indexed as

Muscle Fibers, SkeletalMuscular Dystrophy, DuchenneRNA, Long NoncodingAnimalsCell DifferentiationHumansMiceMice, Inbred mdxMuscle DevelopmentMuscle, SkeletalMyoblastsRNA, Long NoncodingagingCYTORdifferentiationdystrophyfunctional domainlong noncoding RNAmyoblastmyogenesisRNA structuresarcopeniaskeletal muscle

Identifiers

PMID39960339
PMCPMC12120708

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.