ReviewInflammopharmacology2025
Rutin: a pain-relieving flavonoid.
Review in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Metabolic Engineering Strategies for Flavonoid Biosynthesis in Saccharomyces cerevisiae: Current Advances and Future Perspectives.Biotechnology and bioengineering · 2026Review
- Integrated Phytochemical and Pharmacological Investigation ofFood science & nutrition · 2026Article
- Light-driven bacterial inactivation using Plumeria rubra extract: a promising natural photosensitizer.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Modulation of TNF-α, IL-1β and myeloperoxidase contributes to the anti-inflammatory and analgesic effects of Paullinia pinnata Linn (Sapindaceae) extracts in complete Freund's adjuvant-induced mono-arthritis in rats.Journal of ethnopharmacology · 2026Article
- Research Progress and Prospects of Flavonoids in the Treatment of Diseases by Regulating Autophagy: A Narrative Review.Molecules (Basel, Switzerland) · 2026Review
- Rutin as a Potential Therapeutic Agent for Multi-Organ Ischemia-Reperfusion Injury: From Multidimensional Mechanisms to Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
- Potential symbiotic effects of Artemia franciscana extract on post-metabolic response, antioxidant defense, reproductive performance, and tissue integrity in rabbit does.Veterinary research communications · 2026Article
- Microbial communities and metabolome profiles of fermented Chinese mustard greens from diverse regions in Guangdong province, China.Frontiers in microbiology · 2026Article
- Comprehensive Discrimination of Amomi Fructus From Different Origins Using UHPLC-Q-Orbitrap MS, HS-GC-MS/MS, NMR and MIR Technologies Based On Data Fusion Strategies.Analytical science advances · 2025Article
- Bioactive Potential of Wild Plants from Gardunha Mountain: Phytochemical Characterization and Biological Activities.Molecules (Basel, Switzerland) · 2025Article
- Neuroprotective effects of rutin in ischemic stroke: a review.Inflammopharmacology · 2025Review
- Fe₂O₃/Fe-NCA heterojunction nanozyme with oxidase-peroxidase activities for dual-mode simultaneous detection of rutin and puerarin.Mikrochimica acta · 2025Article
- Rutin Ameliorates BHBA-Induced Inflammation and Lipid Accumulation in Calf Hepatocytes Through NF-κB Signaling Pathway.Current issues in molecular biology · 2025Article
- Root-centered sodium sequestration and transcriptomic regulation under salt and alkali stress in wild soybean (Glycine soja).Frontiers in plant science · 2025Article
- Mechanistic Insights into Flavonoid Subclasses as Cardioprotective Agents Against Doxorubicin-Induced Cardiotoxicity: A Comprehensive Review.Drug design, development and therapy · 2025Review
- Molecular mechanisms of neuroprotective effect of rutin.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rutin (vitamin P or rutoside) is a citrus flavonoid glycoside that has shown beneficial health effects in different organs against various conditions including inflammation and pain. The majority of rutin therapeutic benefits are ascribed to its antioxidant and anti-inflammatory properties. This review article discusses studies that investigated pain-relieving activity of rutin and summarizes the reported mechanisms of action. Rutin pain-relieving effect has been studied in streptozotocin-induced diabetes, chronic constriction injury, and oxaliplatin-, formalin-, acetic acid- and glutamate-induced nociception in mice or rats. Based on the literature, rutin analgesic effects are induced through potentiation of antioxidant arsenal, reduction of inflammatory cytokines (e.g., Tumor necrosis factor alpha (TNF-α) and interleukin-1β) levels, suppression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions and modulation of MAPK, NF-κB and Nrf-2/HO-1 signaling. Preclinical findings on rutin pain-relieving activity are promising, however, its safety profile needs to be more thoroughly investigated and clinical trials should be conducted to assess its analgesic effects in humans.
Indexed as
Identifiers
39961908What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.