ArticleScientific reports2025
Role of rich phenolics and betanin profiles from Opuntia ficus-indica fruits in the prevention of diabetic complications using metabolomics study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antidiabetic and Anti-Obesity Effects of Betalains: A Systematic Review of Preclinical Evidence.Molecular nutrition & food research · 2026Pooled it
- An Overview of Metabolomic Approaches to Polyphenol Profiling for Nutraceutical Development.Molecules (Basel, Switzerland) · 2026Review
- Nutritional composition, antioxidant and antimicrobial properties of Opuntia ficus-indica (L) Miller cladodes and fruits.Plant foods for human nutrition (Dordrecht, Netherlands) · 2026Article
- Predicting Nutritional and Morphological Attributes of Fresh CommercialJournal of imaging · 2026Article
- Nanocomposites of Opuntia ficus-indica mucilage-mediated selenium nanoparticles and nanochitosan as antidiabetic candidates in streptozocin-induced diabetic rats.Frontiers in bioengineering and biotechnology · 2026Article
- Improvement of Menopausal Symptoms byFood science & nutrition · 2025Article
- Natural Products from the Mediterranean Area as Wound Healing Agents-In Vitro Studies: A Systematic Review.Antioxidants (Basel, Switzerland) · 2025Review
- Associations of flavonoid intakes with metabolic dysfunction-associated steatotic liver disease in US adults.PloS one · 2025Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Opuntia ficus-indica red fruit (OFI-RF) is a member of the Cactaceae family and native to South America. Phytochemical evaluation of the plant has revealed variable bioactive components; therefore, this study explored the medicinal value of butanol (BE) and ethylacetate extracts (EE) by evaluating their antidiabetic, antioxidant and antihypercholesterolemic properties. Selected solvents were used for phytochemical extraction according to established protocols, and then pharmacological effects of phenolic and betanin-rich extracts were evaluated. Results indicated that butanol was the most effective solvent for extracting polyphenolics followed by ethyl acetate, yielding: 148.91 ± 0.95 and 110.96 ± 0.61 μg/g, respectively. Identification analysis of OFI-RF using UPLC/HESI-MS/MS revealed a diverse range of 101 metabolites, including polyphenolics (phenolic acids, phenolic glycosides, flavanols, flavanonols, flavonoids and biflavonoids), alkaloids, pyridine, betalains, coumarins, vitamins, fatty acids and other therapeutic compounds. Biological studies (in vitro and in vivo) demonstrated that both EE and BE exhibited significant antidiabetic, antioxidant and antihypercholestremic activities. These findings were further supported via histopathological examination.
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