Evidence map›Paper›PMID 39962120›Full record

ArticleScientific reports2025

The potential of the South African plant Tulbaghia Violacea Harv for the treatment of triple negative breast cancer.

Mohammed Alaouna, Thulo Molefi, Richard Khanyile, Nkhensani Chauke-Malinga, Aristotelis Chatziioannou, Thifhelimbilu Emmanuel Luvhengo, Maropeng Raletsena, Clement Penny, Rodney Hull, Zodwa Dlamini

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. The Therapeutic Potential ofMolecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammed AlaounaDepartment of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Thulo MolefiDepartment of Medical Oncology, Steve Biko Academic Hospital, University of Pretoria, Pretoria, 0001, South Africa.
Richard KhanyileDepartment of Medical Oncology, Steve Biko Academic Hospital, University of Pretoria, Pretoria, 0001, South Africa.
Nkhensani Chauke-MalingaPapillon Aesthetics, Suite 302b Netcare Linksfield Hospital, 24 12th Ave, Linksfield West, Johannesburg, 2192, South Africa.
Aristotelis ChatziioannouCenter of Systems Biology, Biomedical Research Foundation of the Academy of Athens, Athens, 11527, Greece.
Thifhelimbilu Emmanuel LuvhengoDepartment of Surgery, Charlotte Maxeke Johannesburg Academic Hospital, University of the Witwatersrand, Parktown, Johannesburg, 2193, South Africa.
Maropeng RaletsenaDepartment of Chemical pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Clement PennyDepartment of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Rodney HullDepartment of Chemical pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Rodney.hull@up.ac.za.
Zodwa DlaminiDepartment of Chemical pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Zodwa.Dlamini@up.ac.za.

Funding

National Research Foundation 138139South African Medical Research Council 23108
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is difficult to treat and has a low five-year survival rate. In South Africa, a large percentage of the population still relies on traditional plant-based medicine. To establish the utility of both methanol and water-soluble extracts from the leaves of Tulbaghia violacea, cytotoxicity assays were carried out to establish the IC

Indexed as

Antineoplastic Agents, PhytogenicPlant ExtractsTriple Negative Breast NeoplasmsApoptosisCell CycleCell Line, TumorCyclooxygenase 2FemaleHumansMolecular Docking SimulationPlant LeavesSouth AfricaAntineoplastic Agents, PhytogenicCyclooxygenase 2Plant ExtractsApoptosis inductionCell cycle regulationComputational dockingCOX-2Cytotoxicity assaysMolecular compound isolationTraditional plant-based medicineTriple negative breast cancer (TNBC)Tulbaghia Violacea

Identifiers

PMID39962120
PMCPMC11832780

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.