Evidence map›Paper›PMID 39963168›Full record

ArticleERJ open research2025

Sleep apnoea, cognition and aspirin's effects in healthy older people: an ASPREE substudy.

Stephanie A Ward, Robyn L Woods, Matthew T Naughton, Rory Wolfe, Danijela Gasevic, Garun S Hamilton, Walter P Abhayaratna, Katherine Webb, Fergal J O'Donoghue, Nigel Stocks and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Development and Validation of Polygenic Scores for Retinal Vessel Calibers.Investigative ophthalmology & visual science · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stephanie A WardSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.ORCID https://orcid.org/0000-0002-1439-3373
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Matthew T NaughtonThe Department of Respiratory Medicine, Alfred Hospital, and The Central Clinical School, Monash University, Melbourne, VIC, Australia.
Rory WolfeSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Danijela GasevicSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Garun S HamiltonDepartment of Lung, Sleep, Allergy and Immunology, Monash Health, Clayton, VIC, Australia.
Walter P AbhayaratnaCollege of Health and Medicine, Australian National University Acton, Canberra, ACT, Australia.
Katherine WebbSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.ORCID https://orcid.org/0000-0002-9380-6075
Fergal J O'DonoghueInstitute for Breathing and Sleep, Austin Health, Heidelberg, VIC, Australia.
Nigel StocksDiscipline of General Practice, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.
Ruth E TrevaksSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Sharyn M FitzgeraldSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Suzanne G OrchardSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Christopher M ReidSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Elsdon StoreySchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI CHAN, ANDREW T, MCNEIL, JOHN JAMES · 2019 to 2023
$42.9M
NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682
6 · The paper itself

Abstract

Importance: Obstructive sleep apnoea (OSA) may increase the risk of dementia; however, studies have reported variable findings. We investigated if undiagnosed OSA in healthy older adults is associated with cognitive decline, and whether low-dose aspirin could attenuate this. Methods: This was conducted as a substudy of the ASPirin in Reducing Events in the Elderly study. Participants were aged 70 years and above, free of dementia, cardiovascular disease and known OSA. A limited channel home sleep study calculated the oxygen desaturation index. Participants were randomised to daily aspirin 100 mg or placebo Results: Mild OSA, detected in 630 (49.0%) participants, and moderate/severe OSA, detected in 405 (31.5%) participants, were associated with lower 3MS scores over 3 years (mild OSA: β Conclusions: OSA was associated with a small decline in global cognition over 3 years in this healthy older cohort. This decline was not attenuated by aspirin.

Identifiers

PMID39963168
PMCPMC11831622

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.