Evidence map›Paper›PMID 39963262›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2025

Cystatin from Austrelaps superbus snake venom as a model for identifying potential inhibitors of Trypanosoma cruzi cruzain.

Jorge Javier Alfonso Ruiz Díaz, Ana Fidelina Gómez Garay, Anderson Makoto Kayano, Rudson Holanda, Aleff Ferreira Francisco, Christian Collins Kuehn, Andreimar Martins Soares, Celeste Vega, Leonardo de Azevedo Calderon

Abstract read
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jorge Javier Alfonso Ruiz DíazCenter for the Development of Scientific Research (CEDIC), Asunción, Paraguay.ORCID https://orcid.org/0000-0003-3189-0037
Ana Fidelina Gómez GarayCenter for the Development of Scientific Research (CEDIC), Asunción, Paraguay.ORCID https://orcid.org/0000-0003-3737-7015
Anderson Makoto KayanoCenter for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation (Fiocruz), Fiocruz Rondônia Unit, Porto Velho, RO, Brazil.ORCID https://orcid.org/0000-0003-4418-7850
Rudson HolandaFederal University of Amazonas (UFAM), AM, Brazil.ORCID https://orcid.org/0000-0002-4599-6265
Aleff Ferreira FranciscoCenter for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation (Fiocruz), Fiocruz Rondônia Unit, Porto Velho, RO, Brazil.ORCID https://orcid.org/0000-0002-6492-5729
Christian Collins KuehnDepartment of Medicine, Federal University of Rondônia, Porto Velho, RO, Brazil.ORCID https://orcid.org/0000-0003-1855-3626
Andreimar Martins SoaresCenter for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation (Fiocruz), Fiocruz Rondônia Unit, Porto Velho, RO, Brazil.ORCID https://orcid.org/0000-0003-1032-2188
Celeste VegaCenter for the Development of Scientific Research (CEDIC), Asunción, Paraguay.ORCID https://orcid.org/0000-0003-3533-3211
Leonardo de Azevedo CalderonCenter for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation (Fiocruz), Fiocruz Rondônia Unit, Porto Velho, RO, Brazil.ORCID https://orcid.org/0000-0003-2669-092X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chagas disease (CD), caused by Methods: Cruzain and AsCystatin were obtained recombinantly through expression in Results: AsCystatin, a potential inhibitor of cysteine proteases, was identified from previously published scientific literature. Conclusion: It was possible to identify AsCystatin and four peptides derived from this protein with inhibitory activity on cruzain, highlighting the trypanocidal effect of these peptides observed in

Indexed as

Chagas diseaseCruzainCystatinsInhibitorsSnake venom

Identifiers

PMID39963262
PMCPMC11832194

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.