ArticleFrontiers in endocrinology2025
Association between the neutrophil-to-high-density lipoprotein cholesterol ratio with kidney stone risk: a cross-sectional study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Association between novel indicators for inflammation and metabolism and kidney stones: a cross-sectional analysis of NHANES 2007-2018.BMC urology · 2026Article
- Association of neutrophil/high-density lipoprotein cholesterol ratio with the cardiovascular-kidney-metabolic syndrome and its cardiovascular mortality.Frontiers in nutrition · 2025Article
- Association between neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and psoriasis risk: a nationally representative cross-sectional study.Frontiers in immunology · 2025Article
- BMI mediates the association between red cell distribution width to serum albumin index and kidney stone risk: a population-based study.Therapeutic advances in urologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Kidney stones are a major issue for public health worldwide. Discovering potential clues in identifying at-risk individuals is essential for early detection and timely treatment. This study explores the relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) with the risk of kidney stones in U.S. adults. Methods: The analysis involved 24,532 participants with available NHR and kidney stone data from the 2007-2018 NHANES period. Multivariable logistic regression models were used to quantify the relationship between NHR and kidney stone occurrence. Subgroup analyses were conducted to explore variations in effect. Results: A total of 2,351 participants (9.93%) were diagnosed with kidney stones, and their mean age was 47.20 ± 0.26 years. After full adjustment in the multivariable regression model, higher NHR levels were linked to a greater risk of kidney stones (OR = 1.05, 95% CI: 1.02-1.08, P = 0.002). Participants in the highest tertile of NHR had a 34% increased chance of kidney stone development compared to those in the lowest tertile. A nonlinear connection between NHR and kidney stone risk was identified using restricted cubic spline (RCS) regression models. The relationship between NHR and kidney stone prevalence showed no significant variation across most subgroups (P for interaction > 0.05). Conclusion: The results indicate that increased NHR is linked to a higher risk of kidney stones, with this relationship remaining consistent across various populations. NHR could be a useful biomarker for kidney stone risk, with key implications for early detection and individualized treatment.
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