Evidence map›Paper›PMID 39965246›Full record

ArticleAging and disease2024

Upregulation of Na/H Exchanger in Astrogliosis and Early Alzheimer's Disease Pathogenesis.

Jenelle M Collier, Shamseldin Metwally, Mary McFarland, Sanjana Krishna, Pallavi Kurella, Victoria Fiesler, Mark Stauffer, Gulnaz Begum, Julia Kofler, Dandan Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jenelle M CollierCenter for Neuroscience at the University of Pittsburgh, School of Medicine, Pittsburgh, PA 15240, USA.
Shamseldin MetwallyDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15240, USA.
Mary McFarlandDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15240, USA.
Sanjana KrishnaDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Pallavi KurellaDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15240, USA.
Victoria FieslerDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15240, USA.
Mark StaufferDepartment of Neuropathology, University of Pittsburgh, PA 15260, USA.
Gulnaz BegumDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15240, USA.
Julia KoflerDepartment of Neuropathology, University of Pittsburgh, PA 15260, USA.
Dandan SunDepartment of Neurology, the Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15240, USA.

Funding

Research Education ComponentP30AG066468 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Julia K Kofler · 2020 to 2026
$29.4M
Predoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0M
Astrocytic Na/H exchanger in AD astrogliosisF31AG084260 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COLLIER, JENELLE MONET · 2024 to 2024
$49k
BLRD VA I01 BX004625BLRD VA I01 BX006372BLRD VA IK6 BX005647NIA NIH HHS F31 AG084260NIA NIH HHS P30 AG066468NINDS NIH HHS T32 NS007433
6 · The paper itself

Abstract

Reactive astrogliosis has been indicated as one of the earliest pathological biomarkers in Alzheimer's Disease (AD) pathology. We previously reported that upregulation of the Na

Indexed as

Alzheimer DiseaseAstrocytesBrainGliosisSodium-Hydrogen Exchanger 1Sodium-Hydrogen ExchangersAgedAged, 80 and overAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalFemaleGlial Fibrillary Acidic ProteinHumansMaleMiceAmyloid beta-Protein PrecursorGlial Fibrillary Acidic ProteinSLC9A1 protein, humanSlc9a1 protein, mouseSodium-Hydrogen Exchanger 1Sodium-Hydrogen Exchangers

Identifiers

PMID39965246
PMCPMC12539526

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.