ArticleNeuro-degenerative diseases2025
Sex Differences for Social Determinants Associated with Lewy Body Dementia Onset and Diagnosis.
Article in Neuro-degenerative diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Race, Social Context, and Caregiving Intensity: Impact on Depressive Symptoms Among Spousal Caregivers.International journal of environmental research and public health · 2025Article
- Sex and gender differences in Lewy body dementia: a narrative review.Equity neuroscience · 2025Article
Corrections and comments
- Erratum issuedErratum.2025
Authors and funding
8 authors.
Funding
Abstract
introductionMultiple studies report sex and gender differences in Lewy body dementia (LBD); however, there is a paucity of research investigating social determinants associated with LBD.
methodsParticipants with LBD (51 females, 79 males) and controls with similar age (64 females, 60 males) completed remote surveys assessing various social and demographic variables, and age at LBD onset for LBD group. Sex-stratified comparisons for LBD and control groups, and comparisons of females and males with LBD were done for social determinants. Sex differences for onset age were further analyzed with linear models adjusting for significantly differing social variables between the sexes.
resultsLBD group had lower years of education, income, subjective social status than controls, with larger differences for males than females (p < 0.05 for all). Higher percentage of females with LBD was living alone (p = 0.016) and not married/partnered (p = 0.002) compared to males with LBD. Adjusting for social variables that differed between the sexes, females were younger at cognitive impairment onset (p = 0.037) and diagnosis (p = 0.032). For the overall cohort, being ethnoracial minoritized, sexual and gender minoritized, and having lower education quality were associated with younger age at symptom onset (p < 0.049 for all). For females, lower childhood subjective social status (p = 0.037), and for males, being ethnoracial minoritized (p < 0.001) and lower years of education (p = 0.031) were associated with younger age at diagnosis.
conclusionSocial determinants, even during childhood, can impact the LBD onset differently for females and males. Interactions between biological and social factors need to be investigated further with inclusive and diverse cohorts in LBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.