Evidence map›Paper›PMID 39965641›Full record

ArticleJournal of the Royal Society, Interface2025

Aortic stretch and recoil create wave-pumping effect: the second heart in the systemic circulation.

Arian Aghilinejad, Coskun Bilgi, Haojie Geng, Niema M Pahlevan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Royal Society, Interface, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arian AghilinejadDivision of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0001-5231-427X
Coskun BilgiDepartment of Aerospace & Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.
Haojie GengDepartment of Aerospace & Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.
Niema M PahlevanDepartment of Aerospace & Mechanical Engineering, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-7498-0396

Funding

American Heart AssociationNational Science Foundation
6 · The paper itself

Abstract

Wave propagation in the heart tube is key to establishing an early pumping mechanism, as explained by impedance pump theory in zebrafish. Though initially proposed for embryonic blood circulation, the role of impedance-like behaviour in the mature cardiovascular system remains unclear. This study focuses on the understudied physiological mechanism of longitudinal displacement in the adult aorta caused by the long-axis motion of the heart. Using magnetic resonance imaging on 159 individuals, we compared aortic displacement profiles between a control group and those with heart failure, revealing a significant difference in aortic stretch between the two groups. Building on this clinical evidence, we conducted

Indexed as

AortaHeartHeart FailureModels, CardiovascularAdultAgedAnimalsFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedaortabiofluid dynamicscardiovascular systempulsatile flowwave pumping

Identifiers

PMID39965641
PMCPMC11835490

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.