ArticleJACC. CardioOncology2025
Effects of Systemic Anticancer Treatment on Cardiorespiratory Fitness: A Systematic Review and Meta-Analysis.
Article in JACC. CardioOncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Mechanisms Underlying Reduced Peak Oxygen Uptake in Older Long-Term Breast Cancer Survivors.JACC. Advances · 2026Article
- The intersection of colorectal cancer and cardiovascular disease: shared mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Follow-up effects of exercise-based interventions on physical performance in cancer survivors: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2026Review
- A Scoping Review on Exercise Interventions During Adjuvant Chemotherapy or Radiotherapy for Cancer.Cureus · 2026Review
- Exercise in regional breast cancer with neoadjuvant anthracycline-based chemotherapy with immune checkpoint-inhibition: study protocol for a prospective randomised controlled trial.Frontiers in oncology · 2026Article
- Impact of Prehabilitation Components on Oxygen Uptake of People Undergoing Major Abdominal and Cardiothoracic Surgery: A Network Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2025Review
- Associations of Breast Cancer Treatments with One-Year Changes in Health-Related Fitness.Cancers · 2025Article
- Effects of Aerobic Exercise on Cardiorespiratory Fitness and Cardiovascular Risk Factors in Long-Term Breast Cancer Survivors: A Randomized Controlled Trial.JACC. CardioOncology · 2025Article
- Exercise Training in Breast Cancer Survivors: A Call for a Mechanistic Understanding of Exercise Physiology.JACC. CardioOncology · 2025Article
- Immune Checkpoint Inhibitors: Think Beyond Cardiotoxicity! Is Physical Deconditioning a New Marker of Disease?Echocardiography (Mount Kisco, N.Y.) · 2025Article
- Exercise Prescription in Cardio-Oncology.Journal of clinical medicine · 2025Review
- Impaired Cardiorespiratory Fitness in Cancer Survivors: Time to Come Together to Solve a Complex Problem.JACC. CardioOncology · 2025Article
- An interdisciplinary approach to ensure adherence to exercise and potentially reduce adverse cardiac events in cancer patients: primers in cardio-oncology.Frontiers in oncology · 2025Article
- Evaluation of a 12-week Mediterranean diet-based nutritional and educational programme for breast cancer survivors: impact on BMI, fatigue, dietary adherence, and menopausal symptoms.Frontiers in nutrition · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundPoor cardiorespiratory fitness (CRF) is associated with a higher symptom burden and an increased prevalence of long-term treatment-related cardiovascular disease risk factors in cancer survivors. However, the magnitude of systemic therapy-related CRF impairment remains unclear.
objectivesThe aim of this study was to evaluate the effects of systemic anticancer treatment on CRF and identify physiological determinants underpinning CRF impairment.
methodsA systematic literature search was performed in PubMed, Embase, CINAHL, SPORTDiscus, and the Cochrane Library. The primary endpoint was the change in CRF, measured by peak oxygen consumption (Vo
resultsA total of 44 studies were included, comprising 27 prospective trials (61%; n = 1,234 cancer survivors, median age 52.4 years) and 17 cross-sectional studies (39%; n = 1,372 cancer survivors, median age 54.0 years; n = 1,923 noncancer control subjects, median age 56.0 years). Systemic anticancer treatment was associated with a significant decrease in Vo
conclusionsSystemic anticancer treatment leads to substantial and sustained impairments in CRF.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.