Evidence map›Paper›PMID 39967965›Full record

ArticleInternational journal of ophthalmology2025

Brain activity in different brain areas of patients with diabetic vitreous hemorrhage according to voxel-based morphometry.

Li-Jun Ji, Jin-Yu Hu, Yan-Mei Zeng, Qian Ling, Jie Zou, Cheng Chen, Liang-Qi He, Xiao-Yu Wang, Hong Wei, Xu Chen and 3 more

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Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Li-Jun JiDepartment of Ophthalmology, Dahua Hospital, Shanghai 200237, China.
Jin-Yu HuDepartment of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China.
Yan-Mei ZengDepartment of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China.
Qian LingDepartment of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China.
Jie ZouDepartment of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China.
Cheng ChenDepartment of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China.
Liang-Qi HeDepartment of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China.
Xiao-Yu WangDepartment of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China.
Hong WeiDepartment of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China.
Xu ChenOphthalmology Centre of Maastricht University, Maastricht 6200MS, Limburg Provincie, the Netherlands.
Yi-Xin WangSchool of optometry and vision science, Cardiff University, Cardiff, CF24 4HQ, Wales, UK.
Yi ShaoDepartment of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China.
Yao YuDepartment of Endocrine and Metabolic, the First Affiliated Hospital of Nanchang University, Jiangxi Clinical Research Centre for Endocrine and Metabolic Disease, Jiangxi Branch of National Clinical Research Center for metabolic Disease, Nanchang 330006, Jiangxi Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo elucidate the neuropathological mechanisms underlying diabetic vitreous hemorrhage (DVH) and its correlation with clinical characteristics.

methodsTwenty-one individuals with DVH (male/female 12/9; mean age 52.29±11.66y) were selected, alongside 21 appropriately matched controls with diabetes mellitus (DM). Voxel-based morphometry (VBM) techniques were employed to identify aberrant functional regions in the brain. Receiver operating characteristic (ROC) curves were utilized for classification based on the average VBM values of the two groups, and Pearson correlation analysis was conducted to assess the relationship between average VBM values in distinct brain regions and clinical manifestations.

resultsRelative to the DM controls, DVH patients exhibited reduced VBM values in the right superior temporal pole, the right superior temporal gyrus, the right medial orbital frontal gyrus, and the left superior frontal gyrus. Furthermore, ROC curve analysis of these four brain regions in DVH patients demonstrated a high degree of accuracy, as indicated by the area under the curve. The average VBM value in each of these regions exhibited a negative correlation with both the duration of DVH and the score on the Hospital Anxiety and Depression Scale (HADS).

conclusionPathological alterations in four distinct brain regions are observed in patients with DVH, potentially reflecting neuropathological changes associated with this condition.

Indexed as

brain areasdiabetic vitreous hemorrhageHospital Anxiety and Depression Scalevoxel-based morphometry

Identifiers

PMID39967965
PMCPMC11754023

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.