Evidence map›Paper›PMID 39968429›Full record

ArticleCureus2025

Experimental Induction of Mammary Carcinogenesis Using 7,12-Dimethylbenz(a)anthracene and Xenograft in Rats.

Adamantia Kontogeorgi, Ioannis Boutas, Nektarios I Koufopoulos, Dionysios T Dimas, Kyparissia Sitara, Antonios Makrigiannakis, Dimitrios Goutas, Sophia Kalantaridou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Adamantia KontogeorgiMedical School, University of Crete, Heraklion, GRC.
Ioannis BoutasBreast Unit, Rea Maternity Hospital, Athens, GRC.
Nektarios I KoufopoulosSecond Department of Pathology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Dionysios T DimasBreast Unit, Athens Medical Center, Psychiko Clinic, Athens, GRC.
Kyparissia SitaraDepartment of Internal Medicine, Elpis General Hospital of Athens, Athens, GRC.
Antonios MakrigiannakisDepartment of Obstetrics and Gynecology, University of Crete, Heraklion, GRC.
Dimitrios GoutasDepartment of Pathology, National and Kapodistrian University of Athens, Athens, GRC.
Sophia KalantaridouThird Department of Obstetrics and Gynecology, School of Medicine, National and Kapodistrian University of Athens, Athens, GRC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBasic research using animal models is essential for investigating pathogenic molecular mechanisms and exploring new pharmaceutical treatments for tumors, including breast tumors. METHODS AND

resultsThirty-six female Wistar rats, four weeks old, were included in the study, but six were excluded early due to health complications, leaving 30 rats in the final cohort. Mammary gland tumors were induced using a single subcutaneous dose of 20 mg 7,12-dimethylbenz(a)anthracene (DMBA) on the right side and MCF7 cells (xenograft) on the left thoracic gland. The experiment spanned 28 weeks. Blood and white cell counts were monitored at the start, mid-point, and end of the study. Tumorigenesis was achieved via both DMBA and MCF7 xenograft. Ovariectomy was performed on all rats, and tumors became palpable after the fifth week following DMBA and MCF7 administration.

conclusionsOncogenesis using DMBA and MCF7 xenograft simultaneously had not been previously attempted. The results showed a 16.7% (6/36) animal mortality rate in the early stages of experimentation and a 100% induction of palpable tumors in the surviving animals.

Indexed as

animal modelbiomodulatorsexperimentmammary carcinogenesismolecular mechanismsovariectomyratsxenograft

Identifiers

PMID39968429
PMCPMC11833382

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.